Mechanism of action of hydroxychloroquine in diabetes

Discussion in 'Aralen 150 Mg' started by del_liero, 16-Mar-2020.

  1. wo1 User

    Mechanism of action of hydroxychloroquine in diabetes


    It may have both an anti-spirochaete activity and an anti-inflammatory activity, similar to the treatment of rheumatoid arthritis. And caution is required if patients have certain heart conditions, diabetes, psoriasis etc.

    Hydroxychloroquine urine color Plaquenil-induced macular degeneration

    Hydroxychloroquine HXCHL is an antimalarial drug that may have antihyperglycemic properties in patients with diabetes. One previous 6 month blinded study reported that HXCHL decreased glycated hemoglobin GHb by an absolute amount of 3.3% when added to patients with type 2 diabetes who were refractory to high doses of insulin or pills. The mechanism by which HCQ works to improve glycemic control in patients with type 1 diabetes is not known and our case seems to be the first case report in the literature. Since HCQ is an immunomodulatory drug has an inhibitory and an immunomodulatory effect on T cells and interleukin 1. Hydroxychloroquine is classified as an anti-malarial drug. It is similar to chloroquine and is useful in treating several forms of malaria as well as lupus erythematosus and rheumatoid arthritis. Its mechanism of action is unknown. Malarial parasites invade human red blood cells.

    The most serious adverse effects affect the eye, with dose-related retinopathy as a concern even after hydroxychloroquine use is discontinued. The most common adverse effects are a mild nausea and occasional stomach cramps with mild diarrhea.

    Mechanism of action of hydroxychloroquine in diabetes

    Plaquenil hydroxychloroquine sulfate dosing, indications., A favorable effect of hydroxychloroquine on glucose and lipid.

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  7. The mechanisms of action of hydroxychloroquine and chloroquine remain under continuous study in modern molecular medicine 17,18 using advanced tools in computational biology 19, synthetic biology.

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    Hydroxychloroquine oral tablet is used for short-term treatment of malaria, but it may be used for long-term treatment of lupus or rheumatoid arthritis. Hydroxychloroquine comes with risks if you. Hydroxychloroquine is also a disease-modifying anti-rheumatic drug DMARD that has immunomodulatory and anti-inflammatory effects. The exact hydroxychloroquine mechanism of action is unclear, although it does work to interrupt the communication of immune system cells to decrease swelling, pain, and joint damage. 1, 2, 3, 5 Its mechanism of action is unknown. Malarial parasites invade human red blood cells. Hydroxychloroquine may prevent malarial parasites from breaking down metabolizing hemoglobin in human red blood cells. Hydroxychloroquine is effective against the malarial parasites Plasmodium vivax, P. malariae, P. ovale, and susceptible strains of P

     
  8. OnLeon Moderator

    Was told by the doctor that the med, should help me control the systemic arthrirts(Sjogren syndrome /lupus) after 4-6 months of using the med. I am on plaquenil but also experience some of the same things you do. Plaquenil Hydroxychloroquine for Lupus - LupusCorner Hydroxychloroquine Side Effects, Dosage, Uses, and More Hydroxychloroquine - CardioSmart
     
  9. UnErrorNeil Well-Known Member

    Hydroxychloroquine Side-effects, uses, time to work Over the long term hydroxychloroquine can reduce pain, swelling and joint stiffness. If you have lupus, it may also improve the rash. It may be as long as 12 weeks before you notice the benefits. Hydroxychloroquine is often taken in combination with other drugs such as methotrexate.

    The Role of Hydroxychloroquine Blood Levels in SLE.
     
  10. Aidarovich XenForo Moderator

    Shaking on the insides - May 09, 2010 when i get the internal shakes some drs laugh at me i always check my BP if thats normal check my sugar level if that is normal i chalk it up to anxiety. the internal shakes feel weird because on the outside you look fine but on the inside your shaking.weird experience. with your heart racing like that i would think anxiety. because your thinking the worst and it can force yourself.

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