Chloroquine pancreatic cancer

Discussion in 'Aralen' started by ProRega, 05-Mar-2020.

  1. qquwka Moderator

    Chloroquine pancreatic cancer


    Note: based on a RGCC chemosensitivity analysis I have seen at a German clinic, Hydroxychloroquine has been effective in killing the cancer cells of 5 out 7 patients that were tested. It is one of very few available drugs that inhibits autophagy, a mechanism associated with its anticancer properties.

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    Pancreatic cancer just diagnosed - asking for advice 4 days ago Recent patent on combination of antagonists of dopamine receptors, glycolysis inhibitor, and a cholesterol lowering agent to inhibit the growth of pancreatic cancer Pancreatic cancer is notoriously treatment resistant. These tumors rely on lysosome-dependent recycling pathways to generate substrates for metabolism, which are inhibited by chloroquine CQ and its derivatives. However, clinical efficacy of CQ as a monotherapy or combined with standard-of-care regimens has been limited. Using an unbiased kinome screen, we identify replication stress as an. Realizing that profuse activation of autophagy may contribute to pancreatic tumor growth, researchers designed an experiment in which they planned to treat the pancreatic cancer cell lines with Chloroquine, already known as inhibitor of autophagy. As a control, chloroquine was also used to treat normal cell lines with low expression of autophagy.

    In cancer, authophagy is the process used by cancer cells to “self-eat” in order to survive. Specifically, if authophagy is prolonged this will become a lethal process to cancer. duing chemotheraphy, radiotheraphy, etc.) authophagy is used by cancer cells to survive. However, note that Chloroquine has other properties as well that may be very well related to anti cancer mechanism, such as zinc ionophore, and others (see below the section on mechanisms).

    Chloroquine pancreatic cancer

    Malaria drug could be used to treat pancreatic cancer - Pancreatic., Lysosome inhibition sensitizes pancreatic cancer to replication stress.

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  5. Summary. Chloroquine is an anti-malarial drug available at pharmacies for people traveling to area with malaria risks. Note based on a RGCC chemosensitivity analysis I have seen at a German clinic, Hydroxychloroquine has been effective in killing the cancer cells of 5 out 7 patients that were tested.

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    Chloroquine should be further explored in the clinical setting as its success may help to more rapidly improve the poor prognosis of patients with pancreatic cancer. ©2014 American Association for Cancer Research. Chloroquine reduces hypercoagulability in pancreatic cancer through inhibition of neutrophil extracellular traps Abstract. The hypercoagulable state associated with pancreatic adenocarcinoma PDA. Background. Pancreatic cancer is associated with a hypercoagulable state resulting in a high. Chloroquine eliminates pancreatic cancer stem cells In an effort to identify more effective treatments against pancreatic CSCs, we established a novel low-throughput drug-screening platform for identifying compounds targeting CSCs unpublished observations; Irene Miranda-Lorenzo.

     
  6. MERLOT New Member

    In the US, Hydroxychloroquine (hydroxychloroquine systemic) is a member of the following drug classes: antimalarial quinolines, antirheumatics and is used to treat Dermatomyositis, Lyme Disease - Arthritis, Malaria, Malaria Prevention, Rheumatoid Arthritis, Sjogren's Syndrome, Systemic Lupus Erythematosus and Undifferentiated Connective Tissue Disease. PLAQUENIL HYDROXYCHLOROQUINE SULFATE TABLETS, USP DESCRIPTION Plaquenil - Antirheumatic Agents, Antimalarials, Amebicides. Plaquenil is the name of the medicine? its a brand. what.
     
  7. bol'shoy Guest

    Chloroquine has long been used in the treatment or prevention of malaria from Plasmodium vivax, P. malariae, excluding the malaria parasite Plasmodium falciparum, for it started to develop widespread resistance to it. Animal toxicity and pharmacokinetics of hydroxychloroquine. Pharmacokinetics of the Antimalarial Drug, AQ-13, in Rats. Pharmacokinetics of Chloroquine and Metronidazole in Rats.
     
  8. larstas User

    Does Plaquenil hydroxychloroquine cause weight loss ? I. Plaquenil hydroxychloroquine can cause some loss in appetite, but 30 pounds in three months is extreme and needs a thorough investigation. You doctor will help and may also advise stopping it temporarily.

    Hydroxychloroquine and weight gain - Answers on HealthTap