Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it. What should a nurse monitor when taking hydroxychloroquine Hydroxychloroquine 부작용 A randomized controlled trial of chloroquine for the treatment of dengue in Vietnamese adults. Tricou V1, Minh NN, Van TP, Lee SJ, Farrar J, Wills B, Tran HT, Simmons CP. Author information 1Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Viet Nam. Oct 01, 2018 Chloroquine phosphate tablets should not be used in these conditions unless the benefit to the patient outweighs the potential risks. Usage in Pregnancy Usage of Chloroquine during pregnancy should be avoided except in the prophylaxis or treatment of malaria when the benefit outweighs the potential risk to the fetus. Inhibition of the TNFα receptor was also reported in U937 monocytic cells treated with chloroquine. In the Dengue virus model, chloroquine was found to inhibit interferon-alpha IFNα, IFNβ, IFNγ, TNFα, IL-6 and IL-12 gene expression in U937 cells infected with Dengue-2 virus. 5. Conclusion The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead. Chloroquine dengue A research study of the role of chloroquine in. - ISRCTN, Chloroquine - FDA prescribing information, side effects and uses Does hydroxychloroquine cause anxietyPlaquenil common side effectsPlaquenil allergic reactionPlaquenil to treat psoriasisWhat is the half life of chloroquine Hydroxychloroquine HCQ is an antimalarial drug also used in treating autoimmune diseases. Its antiviral activity was demonstrated in restricting HIV infection in vitro; however, the clinical implications remain controversial. Infection with dengue virus DENV is a global public health problem, and we lack an antiviral drug for DENV. Hydroxychloroquine-Inhibited Dengue Virus Is. New insights on the antiviral effects of chloroquine against.. Repurposing of the anti-malaria drug chloroquine for Zika.. Zika virus ZIKV is a single-stranded RNA virus primarily transmitted by mosquitos and closely related to dengue virus DENV, another member of the Flaviviridae family Musso and Gubler, 2016. It was first identified in 1947 from a rhesus monkey in the Zika forest of Uganda Dick et al. 1952. The objective of this study was to investigate the use of chloroquine CLQ as an antiviral agent against dengue. Chloroquine, an amine acidotropic drug known to affect intracellular exocytic pathways by increasing endosomal pH, was used in the in vitro treatment of U937 cells infected with dengue virus type 2 DENV‐2. Viral replication was assessed by quantification of virus produced. Dengue viruses are the most important arthropod-borne viruses in terms of morbidity and mortality in the world. Since there is no dengue vaccine available for human use, we have set out to investigate the use of chloroquine as an antiviral drug against dengue.