Pattern of Retinopathy: Although the locus of toxic damage is parafoveal in many eyes, Asian patients often show an extramacular pattern of damage. Dose: We recommend a maximum daily HCQ use of 5.0 mg/kg real weight, which correlates better with risk than ideal weight. Valtrex and plaquenil What does plaquenil do to the immune system Plaquenil retinal toxicity dosage Can plaquenil cause low platelets The American Academy of Ophthalmology has published several dosing and screening recommendations for hydroxychloroquine to avoid potential retinal toxicity, yet some patients still experience. Plaquenil is not deposited into fat,” he explains. “That is why it is recommended that we go by ideal body weight, or IBW—taking into account lean body mass more so than any extra fat mass in people who are overweight.” The American Association of Ophthalmology recommends using the "Devine formula" to determine ideal body weight. On examination, a telltale sign of hydroxychloroquine toxicity is a bilateral change in the retinal pigment epithelium of the macula that gives the commonly described appearance of a bull’s-eye. This is a late finding, however, and too late for screening to be useful. Risk of Toxicity: The risk of toxicity is dependent on daily dose and duration of use. There are no similar demographic data for CQ, but dose comparisons in older literature suggest using 2.3 mg/kg real weight. Plaquenil ophthalmology Plaquenil Side Effects on Your Eyes and Vision, Protecting your eyesight when taking Plaquenil Lupus Foundation of. Long term chloroquine effectsPlaquenil guidelines 2018Plaquenil toxicity vf Apr 20, 2011 Although the incidence of macular toxicity is infrequent with Plaquenil use at a dosage of 200mg or 400mg q.d. its visual impact can be devastating. 2,3. The associated classic retinal toxicity is described as a bull’s eye maculopathy ring of depigmented retinal pigment epithelium that spares the foveal area. New Plaquenil Guidelines. Hydroxychloroquine-Induced Retinal Toxicity - American.. Hydroxychloroquine And Chloroquine. - Ophthalmology Review. Eye care specialists provide a valuable service when screening for Plaquenil retinal toxicity and advising the treating physician or rheumatologist with regards to the patient’s risk, safe dosing and appropriate screening procedures. Jun 13, 2019 Once a year while taking Plaquenil. After five years of Plaquenil treatment, when retina damage is likely to begin, you need to see your ophthalmologist every six months. Special tests can help find early damage to the retina before serious problems develop. A risk factor for Plaquenil hydroxychloroquine retinotoxicity is a daily dose that exceeds 5.0 mg of drug per kg of body weight. The tool on the right simply calculates this threshold based on a ppatient’s real body weight. It’s important to understand that the daily dose is only one risk factor for plaquenil retinotoxicity.