B, Brown pigmentation on the legs in another patient who had systemic lupus erythematosus associated with diffuse discoid lupus. The skin biopsy was performed on the brown area distant from discoid lesions. Hydroxychloroquine medline plus Plaquenil weight gain lupus Plaquenil arthritis foundation Plaquenil therapy for sjogrens icd 10 Answer. Plaquenil or hydroxychloroquine has been known to cause a darkened discoloration of skin and/or mucous membranes. This is considered an adverse reaction and should be discussed with your prescriber. It is important to evaluate this color change to make sure there is nothing else wrong. Lichen planus thins the nail plate, which may become grooved and ridged. The nail may darken, thicken or lift off the nail bed onycholysis. Sometimes the cuticle is destroyed and forms a scar pterygium. The nails may shed or stop growing altogether, and they may rarely, completely disappear anonychia. Find patient medical information for Plaquenil Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. B, Presence of iron in the same areas of the dermis (Perls staining, original magnification ×100). Pub Med Google Scholar Crossref Morrison LK, Nordlund JJ, Heffernan MP. Pub Med Google Scholar Costedoat-Chalumeau N, Galicier L, Aumaître O, et al; Group PLUS. Google Scholar Costedoat-Chalumeau N, Amoura Z, Hulot JS, et al. Pub Med Google Scholar Crossref Costedoat-Chalumeau N, Leroux G, Piette J-C, Amoura Z. A, Interstitial and perivascular brown pigmented granules in the dermis (hematoxylin-eosin-safran staining, original magnification ×100). Plaquenil nail changes Plaquenil Uses, Dosage & Side Effects -, Lichen planus DermNet NZ Chloroquine ototoxicityPlaquenil kills The procedure involves Numbing the skin with an injectable anesthetic. Sampling a small piece of skin by using a flexible razor blade, a scalpel, or a tiny cookie cutter called a "punch biopsy". If a punch biopsy is taken, a stitch suture or 2 may be placed and will need to be removed 6–14 days later. Lichen Planus in Adults Condition, Treatments, and.. Plaquenil Oral Uses, Side Effects, Interactions.. Long-Term Side Effects of Plaquenil for Rheumatoid.. To analyze the risk factors for toxic effects, we performed a case-control study comparing these 24 patients with SLE with 517 patients with SLE in the PLUS Plaquenil LUpus Systemic Study who were treated with HCQ and did not have HCQ-induced pigmentation PLUS Study Identifier NCT00413361. Nail abnormalities is reported only by a few people who take Plaquenil. We study 48,911 people who have side effects while taking Plaquenil from Food and Drug Administration FDA. Among them, 5 have Nail abnormalities. Find out below who they are, when they have Nail abnormalities and more. eHealthMe has been monitoring drugs since 2008. RARE side effects. If experienced, these tend to have a Severe expression. Abnormal Liver Function Tests. Acute Liver Failure. Acute Pustular Eruptions On Skin. Bronchospasm. Decreased Blood Platelets. Decreased White Blood Cells.