Hi Dr V, I am at a crossroad of considering to go back on Plaquenil . A year ago I proposed to go off Plaquenil after being on it for 22 years. Hydroxychloroquine sulphate side effects Acr abstracts plaquenil Chloroquine generic Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. PLAQUENIL has been shown to cause severe hypoglycemia including loss of consciousness that could be life threatening in patients treated with and without antidiabetic medications. Patients treated with PLAQUENIL should be warned about the risk of hypoglycemia and the associated clinical signs and symptoms. The normal dose of Plaquenil is 1 tablet a day 200mg/day. Some doctors recommend 2 a day 400mg/day but we find that 1 a day suits most people – the dose can always be increased for a flare. One of the attractions of this medication is its long ‘half-life’ – it stays in the system for days & weeks. If I had joint or muscle aches, I took care of it by resting, Aleve and ice. At my recent eye exam the doctor mentioned I had reached the plaquenil toxicity level and that my retina cells could die (which do not regenerate! My proposal was based on the fact that I had not had any major inflamation that completely shut me down or keep me from being active. What is the half life of plaquenil PLAQUENIL Side Effects, Reviews by Patients -, Plaquenil Hydroxychloroquine Sulfate Plaquenil make you gain weightPlaquenil sjsMethotrexate and hydroxychloroquine Find patient medical information for Plaquenil Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Plaquenil Oral Uses, Side Effects, Interactions, Pictures, Warnings.. Plaqunil rash -. Plaquenil - FDA prescribing information, side effects and uses. There is no Drug half-life increased reported by people who take Plaquenil yet. This review analyzes which people have Drug half-life increased with Plaquenil. It is created by eHealthMe based on reports from Food and Drug Administration FDA, and is updated regularly. Provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Plaquenil is also indicated for the treatment of chronic discoid lupus erythematosus and systemic lupus erythematosus in adults, and for the treatment of acute and chronic rheumatoid arthritis in adults. • Postmarketing cases of life-threatening and fatal cardiomyopathy have been reported with use of Plaquenil and chloroquine.