Treatment of chloroquine resistant malaria in pregnancy

Discussion in 'Canada Pharmacy' started by alive, 16-Mar-2020.

  1. Neo_design User

    Treatment of chloroquine resistant malaria in pregnancy


    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

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    The treatment of malaria in pregnant women has become more challenging in recent years, as many types of malaria are developing resistance to the standard arsenal of drugs. In locations where the dominant form of malaria is still chloroquine-sensitive, chloroquine can be used safely throughout pregnancy. A pregnant 36-year-old Vietnamese refugee with chloroquine-resistant Plasmodium falciparum infection was treated with pyrimethamine and a sulfonamide. This treatment produced rapid clearance of the patient's parasitemia and was associated with a resumption of normal fetal and uterine growth. Because. Oct 01, 2018 Usage of Chloroquine during pregnancy should be avoided except in the prophylaxis or treatment of malaria when the benefit outweighs the potential risk to the fetus. Radioactively tagged Chloroquine administered intravenously to pregnant pigmented CBA mice passed rapidly across the placenta and accumulated selectively in the melanin structures of the fetal eyes.

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    Treatment of chloroquine resistant malaria in pregnancy

    Chloroquine - FDA prescribing information, side effects., Treatment of Chloroquine-Resistant Malaria During Pregnancy.

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  5. Severe malaria in pregnancy. When a pregnant woman presents with severe malaria, the priority is to save her life. The recommended treatment for severe malaria at any time in pregnancy is with parenteral artesunate 31. The SEAQUAMAT trial showed it to be superior to parenteral quinine in Asian adults 32. Once the woman recovers, treatment can be continued with appropriate oral medication.

    • Management of malaria in pregnancy.
    • Chloroquine - FDA prescribing information, side effects and uses.
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    Infections should receive chloroquine prophylaxis 300 mg base po once a week during pregnancy. Education and information regarding choosing a drug to prevent malaria, including a list of all available drugs and reasons for taking or not taking a certain drug. Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link Because the other drugs effective against chloroquine-resistant P falciparum may produce uterine stimulation quinine sulfate or damage the fetal skeleton tetracyclines, the pyrimethamine-sulfonamide combination with folinic acid supplementation may be the best available choice for the treatment and prophylaxis of chloroquine-resistant P falciparum infection in pregnancy, despite its theoretical risk of teratogenicity.

     
  6. Uncle Lexus New Member

    It is preferable that treatment for malaria should not be initiated until the diagnosis has been established by laboratory investigations. Chloroquine - FDA prescribing information, side effects and uses Glucose-6-phosphate dehydrogenase deficiency - Wikipedia Can hydroxychloroquine Plaquenil be prescribed in the.
     
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