Chloroquine and filipin lysosome

Discussion in 'Canadian Drug' started by kozinabzik, 10-Mar-2020.

  1. siniyP XenForo Moderator

    Chloroquine and filipin lysosome


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    Hydroxychloroquine muscle toxicity Plaquenil skin itching Plaquenil altitude sickness What is chloroquine aralen

    Chloroquine is an established antimalarial agent that has been recently tested in clinical trials for its anticancer activity. The favorable effect of chloroquine appears to be due to its ability to sensitize cancerous cells to chemotherapy, radiation therapy, and induce apoptosis. The present study investigated the interaction of zinc ions with chloroquine in a human ovarian cancer cell line. Chloroquine is a known lysosomotropic agent that increases lysosomal pH by accumulating within lysosomes as a deprotonated weak base. To study the effects of lysosomal dysfunction in ARPE-19, it was necessary to establish an in vitro model utilizing chloroquine. Chloroquine is a lysosomotropic weak base, which in the monoprotonated form diffuses into the lysosome, where it becomes diprotonated and becomes trapped. Protonated chloroquine then changes the lysosomal pH, thereby inhibiting autophagic degradation in the lysosomes.

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    Chloroquine and filipin lysosome

    Targeting endosomal acidification by chloroquine analogs., Chloroquine treatment of ARPE-19 cells leads to lysosome.

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  4. Under these conditions, very little receptor was observed at the cell surface suggesting rapid turnover of the receptor and accumulation in the lysosome. Treatment with chloroquine also resulted in lysosomal accumulation, but also appeared to increase GFP-tagged BMPR-II at the cell surface Fig. 2K–N; arrowheads.

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    Jan 23, 2017 The unprotonated form of chloroquine diffuses spontaneously and rapidly across the membranes of cells and organelles to acidic cytoplasmic vesicles such as endosomes, lysosomes, or Golgi vesicles and thereby increases their pH Al‐Bari 2015. Summary Chloroquine is an anti-malarial drug available at pharmacies for people traveling to area with malaria risks. Note based on a RGCC chemosensitivity analysis I have seen at a German clinic, Hydroxychloroquine has been effective in killing the cancer cells of 5 out 7 patients that were tested. It is one of very few available drugsContinue reading Chloroquine & Hydroxychloroquine. Chloroquine CQ or its derivative hydroxychloroquine HCQ has been widely tested in preclinical cancer models as an inhibitor of the autophagy–lysosomal pathway.

     
  5. zeleboba007 Guest

    I have some sort of auto immune issue with lots of joint pain and fatigue. Quinacrine/atabrine alternative to plaquenil How is plaquenil hydroxychloroquine used to treat lupus? Treating Lupus with Anti-Malarial Drugs Johns Hopkins.
     
  6. LaMaS Guest

    Hydroxychloroquine-Induced Retinal Toxicity - American Academy of. Many systemic medications may cause retinal toxicity. One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine Plaquenil, a chloroquine derivative. It is used to treat many diseases including malaria, rheumatoid arthritis and systemic lupus erythematosus.

    Conditions Plaquenil-related Eye Problems Eugene Eye Care
     
  7. sasha.by Moderator

    Hydroxychloroquine DermNet NZ The risk of retinal toxicity is dependent on several factors A daily dose of hydroxychloroquine 5.0 mg/kg using the patient's body weight. Severe renal impairment. Concomitant use of tamoxifen. Duration of use 5 years.

    Hydroxychloroquine Uses, Dosage & Side Effects -