Begin 1-2 days before travel, daily during travel, and for 7 days after leaving. The 4-aminoquinoline drug hydroxychloroquine (HCQ) is reported to be as active as chloroquine (CQ) against falciparum malaria, and less toxic. Natural medicine comparable to hydroxychloroquine How to treat nausea from plaquenil Plaquenil autoimmune hepatitis The investigators aim to test whether the fixed combination of artesunate-mefloquine is superior to chloroquine in order to define the optimal treatment for both uncomplicated P. knowlesi and P. vivax infection in both adults and children in this region. Compare Chloroquine vs Hydroxychloroquine head-to-head with other drugs for uses, ratings, cost, side effects, interactions and more. Chloroquine rated 10.0/10 vs Hydroxychloroquine rated 6.7/10 in overall patient satisfaction. Chloroquine-resistant P. falciparum first developed independently in three to four areas in Southeast Asia, Oceania, and South America in the late 1950s and early 1960s. Since then, chloroquine resistance has spread to nearly all areas of the world where falciparum malaria is transmitted. In such cases, toxicity is likely when CQ–proguanil is administered to persons being treated for autoimmune disease with daily HCQ. Existing prophylactic regimens for areas where there is CQ-resistant malaria recommend CQ with proguanil as an alternative where none of the three preferred regimens (atovaquone–proguanil, doxycycline or mefloquine) is thought suitable. Chloroquine vs mefloquine Artesunate–mefloquine versus chloroquine for treatment of., Chloroquine vs Hydroxychloroquine Comparison - Chloroquine phosphate injection Cannot be used in areas with chloroquine or mefloquine resistance; May exacerbate psoriasis; Some people would rather not take a weekly medication; For trips of short duration, some people would rather not take medication for 4 weeks after travel; Not a good choice for last-minute travelers because drug needs to be started 1-2 weeks prior to travel CDC - Malaria - Travelers - Choosing a Drug to Prevent Malaria. CDC - Malaria - Malaria Worldwide - How Can Malaria Cases.. Chloroquine Oral Uses, Side Effects, Interactions.. Chloroquine and mefloquine. Premium Questions. Can Mefloquine toxicity cause brain damage? MD. In the past year I have noticed that when I climb stairs, usually multiple flights that I will begin to loose track or miss steps. Just turned 48. Mefloquine is active against the erythrocytic stages of Plasmodium species see INDICATIONS. However, the drug has no effect against the exoerythrocytic hepatic stages of the parasite. Mefloquine is effective against malaria parasites resistant to chloroquine see INDICATIONS. Drug Resistance In the United States, currently approved prophylaxis options for nonimmune children are chloroquine, proguanil, mefloquine, and atovaquone-proguanil 16. Resistance to chloroquine among parasites is widespread, and mefloquine has been associated with potentially serious neuropsychiatric side effects 17, 18.