Hydroxychloroquine mechanism of action in rheumatoid arthritis

Discussion in 'Canadian Pharcharmy Online' started by backspark, 29-Feb-2020.

  1. lelemir Guest

    Hydroxychloroquine mechanism of action in rheumatoid arthritis


    It may have both an anti-spirochaete activity and an anti-inflammatory activity, similar to the treatment of rheumatoid arthritis. And caution is required if patients have certain heart conditions, diabetes, psoriasis etc.

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    Hydroxychloroquine HCQ exerts various anti-inflammatory and immunomodulatory effects and is widely used for the treatment of rheumatoid arthritis RA and systemic lupus erythematosus SLE. However, its mode of action is not completely understood 2. Hydroxychloroquine was initially used as an antimalarial drug and subsequently as an immunomodulator in the treatment of rheumatoid arthritis, Sjögren syndrome, and systemic lupus erythematosus. Fox et al. proposed its action as an immunomodulator in 1996, suggesting that it may have an effect on macrophages. This pilot clinical trial of hydroxychloroquine compared with placebo in humans will examine the mechanisms of action of the drug in attenuating the risk of type 2 diabetes mellitus T2DM in patients with pre-diabetes.

    The most serious adverse effects affect the eye, with dose-related retinopathy as a concern even after hydroxychloroquine use is discontinued. The most common adverse effects are a mild nausea and occasional stomach cramps with mild diarrhea.

    Hydroxychloroquine mechanism of action in rheumatoid arthritis

    Diagnosis and Management of Rheumatoid Arthritis - American Family., CLIPPERS Induction and maintenance of remission using hydroxychloroquine

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  7. The antimalarial agents chloroquine and hydroxychloroquine have been used widely for the treatment of rheumatoid arthritis and systemic lupus erythematosus. These compounds lead to improvement of clinical and laboratory parameters, but their slow onset of action distinguishes them from glucocorticoids and nonsteroidal antiinflammatory agents.

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    A review of hydroxychloroquine as used by rheumatologists and its side effects. For more information, please visit. Rheumatoid Arthritis of the hand - Everything. Objectives Hydroxychloroquine HCQ has been used for decades to treat patients with rheumatic diseases, for example, systemic lupus erythematosus SLE, rheumatoid arthritis or the antiphospholipid syndrome APS. Mechanism of action. Hydroxychloroquine increases lysosomal pH in antigen-presenting cells. In inflammatory conditions, it blocks toll-like receptors on plasmacytoid dendritic cells PDCs. citation needed Hydroxychloroquine, by decreasing TLR signaling, reduces the activation of dendritic cells and the inflammatory process.

     
  8. afina077 User

    Eye redness occurs when the vessels in your eye become swollen or irritated. Recommendations on Screening for Chloroquine and. What Is Plaquenil? - American Academy of Ophthalmology Plaquenil Hydroxychloroquine - Side Effects, Dosage, Interactions - Drugs
     
  9. SEManiak Moderator

    Chloroquine MedlinePlus Drug Information Chloroquine phosphate comes as a tablet to take by mouth. For prevention of malaria in adults, one dose is usually taken once a week on exactly the same day of the week. Your doctor will tell you how many tablets to take for each dose.

    WHO Model Prescribing Information Drugs Used in Parasitic.