Heme chloroquine complex

Discussion in 'Canadian Pharmaceuticals Online' started by KostaLink, 26-Feb-2020.

  1. 21008 Well-Known Member

    Heme chloroquine complex


    Chloroquine is able to bind to DNA, and inhibit DNA replication and RNA synthesis which in turn results in cell death. The effect of Chloroquine may also be related to the formation of a toxic heme-Chloroquine complex.

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    Hemozoin from chloroquine-sensitive or -resistant strains had similar affinities for the chloroquine-heme complex. This adds to the body of evidence suggesting that chloroquine resistance is a result of failure of drug to reach the target site, rather than alteration of the target itself. Absorbance spectroscopy provides evidence that chloroquine is capable of extracting haem bound to Pfhrp-2. This was supported by the Kd value, of 37 nM, observed for the haem-chloroquine complex. The native PAGE studies reveal that the formation of the haem-Pfhrp-2 complex is disrupted by chloroquine. In the presence of free heme, chloroquine and quinidine associate with the heme polymer. We have proposed that this association of the quinoline-heme complex with polymer caps the growing heme polymer, preventing further sequestration of additional heme that then accumulates to levels that kill the parasite.

    Chloroquine possesses definite antirheumatic properties. Chloroquine has immuno-modulatory effects, suppressing the production/release of tumour necrosis factor and interleukin 6. Chloroquine inhibits trophozoite hemoglobin degradation through increasing vacuolar p H and inhibiting the activity of vacuolar phospholipase, vacuolar proteases, and heme polymerase.

    Heme chloroquine complex

    NMR Studies of Chloroquine−Ferriprotoporphyrin IX Complex., Mechanism of malarial haem. - PubMed Central PMC

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  6. Chloroquine caps hemozoin molecules to prevent further biocrystallization of heme, thus leading to heme buildup. Chloroquine binds to heme or FP to form what is known as the FP-Chloroquine complex; this complex is highly toxic to the cell and disrupts membrane function.

    • Chloroquine C18H26ClN3 - PubChem.
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    Spin State of Chloroquine-Heme Complexes Formation of a Hemin Tetramer Adduct Article PDF Available in The Open Spectroscopy Journal 21 May 2008 with 78 Reads How we measure 'reads' Polysaccharide iron complex Iferex 150, Ferrex 150, Niferex 150 is a prescription medication used to prevent or treat anemia. Side effects, drug interactions, dosage, storage, and pregnancy safety information should be reviewed prior to taking this medication. In support of this, Balasubramanian et al. 1984 have obtained spectral evidence that a chloroquine-heme complex forms/n situ inside chloroquine treated trophozoites. Sugioka et al. 1987 have also shown that a chloroquine-heme complex is more potent at promoting lipid peroxidation than free heine alone.

     
  7. Klerik123 Well-Known Member

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