Plaquenil is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. Nexium and plaquenil Is chloroquine-primaquine capitalized Lets face it, lupus is a life changer and we need to deal. I had problems with Plaquinal, but upon researching, it is the best drug for us so I stayed with it. Zero problems now.patience! been on cortisone drops for over a year.started at 16 mg day and have now tapered to 2 drops, or 2 mg. Lupus and depression Know the signs and how to get help. Life with lupus can be challenging. With symptoms that come and go, disease flares and remissions, and the uncertainty of what each day will bring, it’s normal to experience feelings of unhappiness, frustration, anger, or sadness. I can only speak for myself and my personal experience. Plaquenil has helped me on many levels on many days. I think, for me, anyway, the depression and anxiety I often feel is due to the autoimmune issues/sjogrens. I have not noticed an increase in depression/anxiety since being on the plaquenil but that is just me. Plaquenil is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. This medicine is not effective against all strains of malaria. Plaquenil depressione Plaquenil Oral Uses, Side Effects, Interactions, Pictures, Warnings., Lupus and depression Know the signs and how to get help. Aralen lupusLysosomal acidification chloroquineOcular side effects hydroxychloroquine Plaquenil, widely used to treat lupus, rheumatoid arthritis and other inflammatory and dermatologic conditions, is very effective, and “the risk of toxicity in the first five years for someone without special risk factors is very low,” Dr. Marmor said. However, risk increases with duration of use. Rx Side Effects New Plaquenil Guidelines and More - American.. Plaquenil causing mood changes and depression?. PLAQUENIL Side Effects, Reviews by Patients -. Hi! I think Plaquenil is the cause of my extreme fatigue too. I am not anemic at this time and I get exhausted just trying to get through the day. I have also been on Plaquenil about three months. All of my arthritis swelling and pain are gone, but the fatigue will not let up! Hope things change for you. Some of the dosage forms listed on this page may not apply to the brand name Plaquenil. For the Consumer. Applies to hydroxychloroquine oral tablet. Along with its needed effects, hydroxychloroquine the active ingredient contained in Plaquenil may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Does Plaquenil affect your temperament. To cut a long story short, my new specialist has put me on plaquenil. For the best part I can notice no change in anything apart from being SO arguementative, being verbally very aggressive and feeling totally out of control. It is causing huge problems btwn my partner and I as he seems to be the.