Chloroquine heme polymerase

Discussion in 'Canadian Pharmacies Without An Rx' started by HDD, 16-Mar-2020.

  1. Chloroquine heme polymerase


    These hematophagous organisms such as Malaria parasites (Plasmodium spp.), Rhodnius and Schistosoma digest haemoglobin and release high quantities of free heme, which is the non-protein component of hemoglobin. Heme is a prosthetic group consisting of an iron atom contained in the center of a heterocyclic porphyrin ring.

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    Chloroquine caps hemozoin molecules to prevent further biocrystallization of heme, thus leading to heme buildup. Chloroquine binds to heme or FP to form what is known as the FP-Chloroquine complex; this complex is highly toxic to the cell and disrupts membrane function. Although the mechanism is not well understood, chloroquine is shown to inhibit the parasitic enzyme heme polymerase that converts the toxic heme into non-toxic hemazoin, thereby resulting in the accumulation of toxic heme within the parasite. This agent may also interfere with the biosynthesis of nucleic acids. Heme is a prosthetic group consisting of an iron atom contained in the center of a heterocyclic porphyrin ring. Free heme is toxic to cells, so the parasites convert it into an insoluble crystalline form called hemozoin. In malaria parasites, hemozoin is often called malaria pigment.

    In malaria parasites, hemozoin is often called malaria pigment. Free heme is toxic to cells, so the parasites convert it into an insoluble crystalline form called hemozoin.

    Chloroquine heme polymerase

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  5. Chloroquine is the most widely used drug against malaria, except for those cases caused by chloroquine resistant Plasmodium falciparum. Although the mechanism of action is not fully understood, chloroquine is shown to inhibit the parasitic enzyme heme polymerase that converts the toxic heme into non-toxic hemazoin, thereby resulting in the.

    • Chloroquine hydrochloride C18H28Cl3N3 - PubChem.
    • Hemozoin - Wikipedia.
    • Heme Polymerase Activity and the Stage Specificity of..

    It has high affinity for chloroquine, which is another mechanism for trapping chloroquine. Once trapped, chloroquine acts by one of many ways a. Inactivation of heme-polymerase responsible for conversion of heme part of hemoglobin into hemozoin. Conversion does not take place, heme is toxic to plasmodium, resulting in death of plasmodium. b. Chloroquine is a 4-aminoquinoline with antimalarial, anti-inflammatory, and potential chemosensitization and radiosensitization activities. Although the mechanism is not well understood, chloroquine is shown to inhibit the parasitic enzyme heme polymerase that converts the toxic heme into non-toxic hemazoin, thereby resulting in the accumulation of toxic heme within the parasite. Chloroquine is thought to exert its antimalarial effect by preventing the polymerization of toxic heme released during proteolysis of hemoglobin in the Plasmodium digestive vacuole. The mechanism of this blockade has not been established. We incubated cultured parasites with subinhibitory doses of 3Hchloroquine and 3H quinidine.

     
  6. Askalibur Moderator

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  7. nozendman Moderator

    Hydroxychloroquine is in a class of drugs called antimalarials. Hydroxychloroquine Oral Route Precautions - Mayo Clinic Hydroxychloroquine - Wikipedia Hydroxychloroquine dosage recommendations often ignored.
     
  8. st0rm Well-Known Member

    Hydroxychloroquine 200 mg Tablets Generic Plaquenil HYDROXYCHLOROQUINE - ORAL hi-DROX-ee-KLOR-oh-kwin COMMON BRAND NAMES Plaquenil. USES Hydroxychloroquine is used to prevent or treat malaria infections caused by mosquito bites. It does not work against certain types of malaria chloroquine-resistant.

    Hydroxychloroquine - Wikipedia
     
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