Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Does plaquenil help fatigue Plaquenil causing lymphoma Rheumatoid arthritis guidelines hydroxychloroquine monotherapy It does take months in the beginning but stuck with it. The fact that it is not damaging to your immune system is a HUGE PLUS. Protect and build your immune ! Know that theUniverse and its forcesGod have built perfection into every fiber of your being! Have the confidence that your body know how to heal itself. May 05, 2010 The fatigue is undending and I just don't have energy to do anything. Is this just a part of RA or could it be the Plaquenil? I know it takes a while to build up in your system. How do you deal with the fatigue? It's really frustrating! SIDE EFFECTS. The following adverse reactions have been identified during post-approval use of PLAQUENIL or other 4-aminoqunoline compounds. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Does plaquenil have to build up in your system Will you have Biliary cirrhosis primary with Plaquenil., Does Plaquenil cause fatigue or fever? - Rheumatoid Arthritis Plaquenil eye exam protocolLupus worse or plaquenil side effectsChloroquine phosphate amazonFang and hydroxychloroquine screeningPlaquenil eye problems Plaquenil is the brand name for the prescription drug hydroxychloroquine. It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as lupus, rheumatoid arthritis, and others. Malaria is spread by mosquitoes. Plaquenil Hydroxychloroquine - Side Effects, Dosage.. Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses. Plaquenil side effects - kidney problems? - Symptoms - Life.. Hydroxychloroquine brand namePlaquenil is a disease-modifying anti-rheumatic drug DMARD approved for adults with RA. It is often given in combination with methotrexate and sulfasalazine a treatment known as triple therapy, to help slow RA disease progression for patients who do not get relief from methotrexate therapy alone. 1,2. Research shows that this medication reduces RA symptoms. I came across this page having the same question. How long does it take for Plaquenil to leave your system after discontinuing use. However, I do not want to stop taking it because of terrible side effects listed by other users of the med. I love this drug. I have never felt as good as I do now. It’s about 45 days before it starts to go out of your system. Remember it is cumulative, and took time to build up for an effect when you started taking it. It has an enormous half life. That’s why I laugh when some people’s surgeons tell them stop taking it 2 weeks before surgery. It does nothing. More up to date Drs will tell you not to.