These, as well as other commonly used medications, can cause various types of allergic reactions that frequently lead to hyperpigmentation (dark patches). There are four primary types of medication reactions that can lead to often troubling and disfiguring hyperpigmentation: A fixed drug eruption is a round, dark patch or eruption that results from a reaction to a drug (usually a prescription medication). Can plaquenil and metoprolol tartrate Plaquenil and methotrexate for sjogren's syndrome Skin figure 1A,B. There was no pigmentation at other body sites. Biopsy from the plaque showed necrobiotic collagen with intradermal mucin and perivascular lymphohistiocytic infiltrate accom-panied by brown coarse pigment in the dermis figure 1C,D. The pigment was negative on Perl’s stain figure 1E. This was a unique pattern of Home August 2013 - Volume 19 - Issue 5 Hydroxychloroquine-Induced Hyperpigmentation. Log in to view full text. If you're not a subscriber, you can Find patient medical information for Hydroxychloroquine Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. The round patch is usually fixed to one spot will appear in this same location within 24 hours of each dose taken. This type of reaction leaves a grey-blue, round patch on the skin. Hydroxychloroquine skin pigmentation Treatment of hydroxychloroquine-induced hyperpigmentation of., Hydroxychloroquine-Induced Hyperpigmentation JCR Journal. Chloroquine disadvantagesPainful muscle spasms from plaquenil Some medications, such as plaquenil and minocycline, can cause permanent dark skin plaques, which resemble black and blue marks similar to morphea scleroderma. Cosmetically, pigmentation differences can be covered up with corrective cosmetics, such as Dermablend. Drug-Induced Hyperpigmentation caused by Minocycline Minocin Antibiotic Systemic Scleroderma Skin Involvement Hyperpigmentation and.. Hydroxychloroquine Oral Uses, Side Effects, Interactions.. Hydroxychloroquine-induced Hyperpigmentation of the Skin.. Skin rashes and pigment change. Atabrine, specifically, can cause yellow pigmentation of skin. Sometimes Plaquenil can also deposit in the tissues of the body and cause the skin to take on a greenish tone. Dry skin Loss of appetite Abdominal bloating Upset stomach Stomach cramps MAIN OUTCOMES AND MEASURES The primary outcome was the clinical features of HCQ-induced pigmentation. Skin biopsies were performed on 5 patients, both in healthy skin and in the pigmented lesions. The statistical associations of HCQ-induced pigmentation with several variables were calculated using univariate and multivariate analyses. A thorough history is essential to determine the cause of a pigmentary disorder. Very important information to gather during the evaluation of the patient includes the temporal relationship of medications taken and the development of the pigmentation, the presence of accentuation from exposure to sunlight, a list of medications taken, and a personal and family history of disorders such as.