It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine mechanism of action ra Lysosomotropic agent chloroquine which Plaquenil alcohol interaction Weaning from hydroxychloroquine Plaquenil lingers in the system at least 50 days and cannot be taken while on the MP. Dr. Blaney reports he starts his patients on Benicar while they are waiting for Plaquenil to clear their system and has seen no adverse events. Aug 27, 2010 can you just stop taking plaquenil or do you have to wean off it. on August 27, 2010, PM i was just curious if i was to try plaquenil again for a few days/weeks if you decide How to use Plaquenil. Hydroxychloroquine is usually taken with food or milk to prevent stomach upset. The dosage and length of treatment are based on your medical condition and response to therapy. In children, dosage is also based on weight. Today, it is used to treat rheumatoid arthritis, some symptoms of lupus, childhood arthritis (or juvenile idiopathic arthritis) and other autoimmune diseases. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. Is it necessary to wean off of plaquenil I have missed 2 days of my Plaquenil- I have questions!, Can you just stop taking plaquenil or do you have to wean off. Chloroquine alcoholDoes plaquenil help psoriatic arthritisBaseline labs required before starting plaquenil The biologics are wonder drugs for many people, but a lot of people also find great relief with just plaquenil. Someone else told me that plaquenil could take up to a year to work. Others have told me that it only took a few months for them to feel the effects. Everyone is different. I can tell you that plaquenil is the safest of all of the DMARDs. Plaquenil -. Plaquenil Oral Uses, Side Effects, Interactions, Pictures.. Hydroxychloroquine Oral Route Proper Use - Mayo Clinic. Although, plaquenil is a DMARD a Disease Modifying Antirheumatic Drug and now at least you have the comfort of knowing that it was, indeed, modifying your disease. Hopefully it will kick in again soon, but it obviously has more work cut out for it, this time around. Typically, that is the drug the patient would prefer to taper. If there are any tolerability issues, methotrexate is likely to be the drug that is driving that. Usually, by that point, the patient does not have tolerability issues that would mean they cannot take it at all. It would be unlikely IMO that the Plaquenil is the cause, since there is tapering necessary when stopping it and no documented 'withdrawal' syndrome associated with it. If you have taken it for a long time, it is probably not even out of your system yet, since Plaquenil has a half-life of 30-60 DAYS not hours.