Hydroxychloroquine is available as the brand-name drug Plaquenil. Generic drugs usually cost less than the brand-name version. Hydroxychloroquine may be used as part of a combination therapy. Benefits of plaquenil for rheumatoid arthritis Plaquenil used for What type muscle weakness with plaquenil Ra medication hydroxychloroquine Medicines that may cause Plaquenil interactions include digoxin, cyclosporine, and mefloquine. This eMedTV resource contains a more detailed list of drugs that may interact with Plaquenil and describes the potential effects of these interactions. Methotrexate Rasuvo, Otrexup is a self-injectable solution used to treat psoriasis and rheumatoid arthritis. Learn about side effects, warnings, dosage, and more. Find patient medical information for Plaquenil Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Hydroxychloroquine is used to treat lupus erythematosus and rheumatoid arthritis. It isn’t fully understood how this drug works to treat lupus erythematosus or rheumatoid arthritis. That means you may need to take it with other drugs. It treats malaria by killing the parasites that cause the disease. Plaquenil methotrexate interactions Plaquenil Oral Interactions with Other Medication, Methotrexate Injection Side Effects, Dosage, Uses, and More Chloroquine diphsophateChloroquine still effective for malaria prophylaxis guatamalaChloroquine and hearing loss Drug Interactions. section was added to the Plaquenil drug label with information regarding use with digoxin, insulin or diabetic drugs, drugs that prolong QT interval and other arrhythmogenic drugs, mefloquine and other drugs known to lower the convulsive threshold, antiepileptics, methotrexate, cyclosporine, Biltricide ® Plaquenil hydroxychloroquine – New Warnings. Plaquenil Oral Uses, Side Effects, Interactions, Pictures.. Compare Plaquenil vs Methotrexate -. Dec 15, 2010 hello hope everyone is well just a quick question, i have been on methotrexate for 2 months increasing from 7.5 to 15 and now to 25mg.weekly now been given plaquenil 400mg daily, has anyone else been on this mixture and has it worked or how long should i wait to see if it works. Drug Interactions. Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Over the past few years, data have appeared that indicate a potential interaction between MTX and proton pump inhibitors PPIs. Evidence of an Interaction. The first case report of a potential interaction between MTX and a PPI was noted in a patient with osteosarcoma who was receiving high-dose 15 g MTX.