Suddenly I'm experiencing eye problems (blilnd spots). I have stopped taking plaquenil, but now I'm being told by doctors that the damage is not necessarily reversible especially if you have taken it for a long time. Intermittent preventive therapy chloroquine Plaquenil pill sjogren's Chloroquine skin pigmentation The toxicity resulting from the intake of Plaquenil is due to its affinity for melanin -containing structures in the body. With prolonged usage, metabolites in the drug accumulate in the retina. The drug remains in these parts even if the patients stopped taking the drugs. She suffered from Sjogren syndrome and inflammatory arthritis and was currently treated with prednisone and methotrexate. She was previously treated with hydroxychloroquine Plaquenil 200mg bid 6.5mg/kg for 10 years, which was stopped one year prior to presentation. So I went to the ophthalmologist which was my third opinion and have been continuing to see him for the past 3 1/2 years. I am going blind because of the retinal atrophy due to the plaquenil Normally after you stop plaquenil your eyes will stay at the damage level that was caused to it, but in rare cases the damage will continue. My mother was diagnosed with Plaquenil Toxicity in 2007 she first noticed changes in 2006, although being followed by her eye doctor they failed to notice this as Plaquenil TX until it was to late. I'm hoping to find people who have recovered from the eye damage. Signs of retinal damage from plaquenil Conditions Plaquenil-related Eye Problems Eugene Eye Care, Hydroxychloroquine Plaquenil Toxicity and Recommendations. Plaquenil 200 mg sanofi aventis Aug 14, 2017 Signs of retinal damage include blurry or distorted vision, flashes of light or floaters, or loss of night vision. Retinal damage may not improve even after Plaquenil is discontinued. Dilated eye exams should be done every six months to check for retinal problems. Long-Term Side Effects of Plaquenil for Rheumatoid Arthritis.. Has anyone experienced plaquenil toxicity with damage to eyes?. Hydroxychloroquine Plaquenil Toxicity and Recommendations for Screening. H ydroxychloroquine HCQ; Plaquenil, Sanofi, Bridgewater, NJ is an antimalarial agent that is also commonly used as a treatment for a variety of rheumatologic and dermatologic conditions, such as rheumatoid arthritis and systemic lupus erythematosus. The most common side effect associated with its use is retinal toxicity, which may be. The side effect that is of greatest concern is retinal toxicity. Retinal toxicity of Plaquenil may manifest itself with subtle disturbances of the retinal pigment epithelium which may eventually lead to complete destruction of the macula in the form of bull’s-eye maculopathy. Plaquenil toxicity is typically asymptomatic in early stages, but over time can lead to severe vision loss and retinal damage. The risk of retinal toxicity was initially believed to be less than 1% after long-term or a cumulative dosage of 1,000mg. 3 The toxicity would double by 10 years, resulting in a 20% prevalence after 20 years. 4.