I don't get many side effects generally, but with prednisone I DO. It does help, but this can't be a long term affair. Plaquenil is a great drug (I have no experience with it, but many people with lupus take it). I'd ask your rheumy about it and have them explain why they made that choice for you. Prednisone is an intermediate acting corticosteroid-which means it has direct anti-inflamitory properties that take effect begining in a few hours. Is plaquenil another option instead of the prednisone? It is ment to get this undercontrol now and diminish your pain. Does plaquenil help raynaud's Plaquenil method of action The prednisone is a steriod and the plaquenil is a anti malaria drug. The thing with plaquenil for me is that I don't notice much of anything taking it but when I go off then I flare up and then really notice it. I have been taking the plaquinil for about 8 years morning and night and the prednisone off and on. Plaquenil hydroxychloroquine is commonly used to help keep mild lupus-related problems, such as skin and joint disease, under control. this drug is also effective at preventing lupus flares. Re Plaquenil - Better Than Prednisone? Have been taking Plaquenil for over a year now and it has definitely made a huge difference in my quality of life. When I first went to my Rhuemy and found out what was wrong, I was so sick I could barely function with fatigue, joint and muscle aches just to name a few. It has not direct anti-inflamitory properties and instead works on the immune system-though the mechanism is not known. Plaq is a longer time medication it may take two months before their is a noticable difference. Plaquenil and prednisone for lupus Prednisone and Immunosupression lupus, How is plaquenil hydroxychloroquine used to treat lupus? Vortex keratopathy hydroxychloroquine I understand this drug is very effective in preventing organ damage and my doctors made me aware of this. I am still a Prednisone refuser. I take Plaquenil, Endep, Pariet, Tramadol and Celebrex to stabilise my Lupus and give pain relief and Atenolol for my heart. I see my rheumatologist every 3 to 4 months and my GP in between times. Prednisone for Lupus DailyStrength. Immune & Autoimmune - Lupus Plaquenil - Better Than.. Immune & Autoimmune - Lupus lupus rash & prednisone. Yes, anti-malarials can be taken with other lupus medications, including corticosteroids e.g. prednisone, immunosuppressives, cytotoxic drugs, and NSAIDs. Anti-malarial drugs may be given in combination with prednisone to reduce the amount of steroid needed to control lupus symptoms and thus to alleviate some of the side effects of the steroid. Lupus nephritis is found among people who take Prednisone and Plaquenil, especially for people who are female, 20-29 old, have been taking the drugs for 5 - 10 years, also take medication Cellcept, and have Pain. This review analyzes which people have Lupus nephritis with Prednisone and Plaquenil. Compare Plaquenil vs Prednisone head-to-head with other drugs for uses, ratings, cost, side effects, interactions and more. Plaquenil rated 6.8/10 vs Prednisone rated 7.7/10 in overall patient satisfaction.