It is generally well tolerated, but retinopathy is a concern. Retinopathy is rare, but is sight threatening, generally irreversible and may progress even after cessation of therapy. Although a number of risk factors have been proposed (such as duration of therapy and cumulative dose), the many exceptions (e.g. Im chloroquine dosage for adults Chloroquine fansidar and mefloquine Plaquenil skin side effects pictures COVER FEATURE Corneal diagnoses and systemic disease Ophthalmologists can diagnose deadly disease at slit lamp by Jena Passut EyeWorld Staff Writer Fabry's disease presents with corneal verticillata A patient with Fabry's disease and a characteristic cornea verticillata Amiodarone deposition in the cornea Source all W. Barry Lee, M. D. Imagine looking into the slit lamp Cornea verticillata, also called vortex keratopathy or whorl keratopathy, is a condition characterised by corneal deposits at the level of the basal epithelium forming a faint golden-brown whorl pattern. It is seen in Fabry disease or in case of prolonged amiodarone intake. Causes. Amiodarone Fabry’s disease Chloroquine Hydroxychloroquine While corneal findings had been thought to have no correlation with the development of retinal toxicity, Aljoscha Neubauer, MD, and colleagues conducted a screening of 93 patients with marked corneal deposits who were taking either chloroquine or hydroxychloroquine, and using electro-oculogram and computerized color vision testing, found a 50%. Novel technologies such as optical coherence tomography (OCT), fundus autofluorescence (FAF) and multifocal electroretinogram (mf ERG) may provide the earliest structural and functional evidence of toxicity in these stages. Retinopathy on low-dose HCQ, or no retinopathy after a very large cumulative dose of HCQ) highlight our limited understanding of the disease process. Cornea verticillata hydroxychloroquine Recommendations on Screening for Chloroquine and., Cornea verticillata - Wikipedia Plaquenil and muscle relaxorHydroxychloroquine issuesHydroxychloroquine success stories If cornea verticillata is associated with a drug that is known to produce retinal toxicities, most notably hydroxychloroquine, chloroquine, chlorpromazine, and tamoxifen, patients should be routinely monitored with automated visual fields plus spectral-domain optical coherence tomography SD OCT 20. Cornea verticillata, causes, symptoms, diagnosis & treatment. When ‘Collateral Damage’ Strikes the Cornea. Chloroquine and Hydroxychloroquine Toxicity Clinical.. Corneal deposits called vortex keratopathy or corneal verticillata result from binding to cellular lipids and deposition of the drug in the basal epithelial layer of the cornea. Discontinuation of the drug usually causes the deposits to disappear over time. Cornea verticillata; Vertex keratopathy Chloroquine toxicity is characterized by whorl-like corneal epithelial deposits. Medications of the chloroquine family, including chloroquine Nivaquine. Ocular manifestations of hydroxychloroquine include corneal verticillata and retinal toxicity. Verticillata are cornea deposits of salts within the corneal epithelium. This condition does not cause symptoms and is reversible with cessation of the medication.