Chloroquine mechanism in the body

Discussion in 'Chloroquine Drug' started by kilboy, 27-Feb-2020.

  1. demirov Moderator

    Chloroquine mechanism in the body


    Note: based on a RGCC chemosensitivity analysis I have seen at a German clinic, Hydroxychloroquine has been effective in killing the cancer cells of 5 out 7 patients that were tested. It is one of very few available drugs that inhibits autophagy, a mechanism associated with its anticancer properties.

    Plaquenil diagnosis code Can hydroxychloroquine be classed as a brand name How to admin chloroquine

    The mechanisms of chloroquine accumulation in the food vacuole have been proposed to be accumulation of chloroquine in the food vacuole as a result of increased acidity, presence of a carrier in the parasite and the presence of a receptor in the vacuole that chloroquine can bind to 10. Chloroquine undergoes appreciable degradation in the body. The main metabolite is desethylchloroquine, which accounts for one fourth of the total material appearing in the urine; bisdesethylchloroquine, a carboxylic acid derivative, and other metabolic products as yet uncharacterized are found in small amounts. Chloroquine is one of the oldest anti-malarial agent, effectively used in malarial infections. P. falciparum and vivax are the sensitive types. It is a rapidly acting drug, targeting the asexual stage. It is an effective blood schizonticidal agent. It is gametocidal, except for P. falciparum.

    In cancer, authophagy is the process used by cancer cells to “self-eat” in order to survive. Specifically, if authophagy is prolonged this will become a lethal process to cancer. duing chemotheraphy, radiotheraphy, etc.) authophagy is used by cancer cells to survive. However, note that Chloroquine has other properties as well that may be very well related to anti cancer mechanism, such as zinc ionophore, and others (see below the section on mechanisms).

    Chloroquine mechanism in the body

    Mechanisms of Chloroquine-Induced Body-Scratching Behavior., Aralen Chloroquine Uses, Dosage, Side Effects.

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  4. Chloroquine-resistant Plasmodium falciparum accumulate significantly less chloroquine than susceptible parasites, and this is thought to be the basis of their resistance. However, the reason for the lower accumulation of chloroquine was unknown. The resistant parasite has now been found to release chloroquine 40 to 50 times more rapidly than the susceptible parasite, although their initial.

    • Efflux of chloroquine from Plasmodium falciparum mechanism..
    • Chloroquine – howMed.
    • Mechanisms of Chloroquine-Induced Body-Scratching Behavior in..

    Chloroquine is also used to treat autoimmune diseases in some countries because of its immunosuppressive properties. Although the precise mechanism underlying the antimalarial effects of chloroquine remains unknown, chloroquine seems to exert its effects through the weak-base lysosome-tropic feature. When chloroquine enters the lysosome, it becomes protonated because of the low pH within the lysosome, and accumulation of the protonated form of chloroquine within the lysosome leads to less. The DMARDs hydroxychloroquine and chloroquine are weak bases that accumulate in acidic compartments such as lysosomes and inflamed acidic tissues. Both hydroxychloroquine and chloroquine have a. Antimalarials modulate or change the way the immune system works. The exact mechanism of action for hydroxychloroquine and another antimalarial drug chloroquine in RA is not known, but researchers think these drugs decrease production of a number of different chemicals that are important to the immune response. 3

     
  5. Chin-U Moderator

    The NICE Clinical Knowledge Summaries (CKS) site is only available to users in the UK, Crown Dependencies and British Overseas Territories. DMARDs - NICE CKS Efficacy of combination DMARD therapy vs. hydroxychloroquine. Hydroxychloroquine–DMARD combination therapy supported for RA.
     
  6. wrernciz Well-Known Member

    Chloroquine has long been used in the treatment or prevention of malaria from Plasmodium vivax, P. malariae, excluding the malaria parasite Plasmodium falciparum, for it started to develop widespread resistance to it. Autophagy Activation in Hepatocellular Carcinoma Contributes. The protein kinase activity of fructokinase A specifies. Tenovin-6 impairs autophagy by. - Cell Death & Disease
     
  7. suharik Well-Known Member

    Primaquine in vivax malaria an update and review on. Chloroquine has been the backbone of vivax treatment regimens since its inception and chloroquine together with primaquine was the standard therapy for vivax malaria on the understanding that P. vivax was universally sensitive to chloroquine. The first patient with chloroquine resistant vivax malaria was reported from Papua New Guinea in 1989.

    Vivax malaria - PubMed Central PMC
     
  8. argee Guest

    Hydroxychloroquine in systemic lupus erythematosus SLE. INTRODUCTION Hydroxychloroquine HCQ is an alkalinizing lysosomatropic drug that accumulates in lysosomes where it inhibits some important functions by increasing the pH. HCQ has proved to be effective in a number of autoimmune diseases including systemic lupus erythematosus SLE.

    Hydroxychloroquine Side Effects, Dosage, Uses, and More