Chloroquine mice scratching

Discussion in 'Chloroquine Drug' started by -IG-, 01-Mar-2020.

  1. vlav Moderator

    Chloroquine mice scratching


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    Sep 25, 2019 The CNO-mediated increase in chloroquine-evoked scratching in mice expressing the inhibitory DREAAD hM4Di in the vlPAG was dose-dependent Supplementary Fig. 1b, and again, this increase in. Peak chloroquine-induced scratching varied by 2.5-fold in this set of strains; scratching behavior shows moderate heritability in the mouse. The present data also reveal, for the first time, significant sex differences in pruritogen-induced scratching behavior, with female mice scratching an average of 23% more than males. We report that chloroquine 1.25–40 mg/kg, s.c. elicits dose-related, compulsive, and vigorous scratching in mice. This frenzied behavior is essentially abolished when the mice are pretreated s.c. or orally with nalfurafine TRK-820, a centrally penetrating kappa opioid agonist.

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    Chloroquine mice scratching

    Chloroquine-induced scratching is mediated by no/cgmp., Influence of genotype, dose and sex on pruritogen-induced scratching.

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    This study validates the anti-itch effects of U-50,488 in a murine chloroquine-induced itch model. Chloroquine-induced Pruritus Scratching Model. Mice were acclimated to testing chambers 30 minutes prior to testing. After acclimation, mice were removed from testing chamber and administered Chloroquine into the right shoulder area. Aug 06, 2009 Both mice have been injected with chloroquine, an antimalarial drug that causes intense itchiness. The one on the left lacks any neurons with active GRPR genes, while the one on the right is normal. Chloroquine was injected intradermally into the rostral back of NMRI mice, and the scratching behavior was evaluated by measuring the number of bouts over 30 min. We evaluated the effect of sumatriptan and combination of sumatriptan and a non‐selective NO synthase inhibitor, L‐N‐nitro arginine methyl ester L‐NAME, on the scratching behavior.

     
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