Treatment of severe chloroquine poisoning

Discussion in 'Chloroquine Online' started by maggots, 19-Mar-2020.

  1. aguri2 Guest

    Treatment of severe chloroquine poisoning

    Note: For a listing of dosage forms and brand names by country availability, see Dosage Forms section(s). General considerations Malaria transmission occurs in large areas of Central and South America, Hispaniola, sub-Saharan Africa, the Indian subcontinent, Southeast Asia, the Middle East, and Oceania . Category: Antiprotozoal—Chloroquine; Antihypercalcemic—Chloroquine (Oral); Antirheumatic (disease-modifying)—Chloroquine (Oral); Lupus erythematosus suppressant—Chloroquine (Oral); Polymorphous light eruption suppressant—Chloroquine (Oral); Porphyria cutanea tarda suppressant—Chloroquine (Oral); Indications Note: Bracketed information in the Indications section refers to uses that are not included in U. Drug resistance to chloroquine has been confirmed or is probable in all countries with Plasmodium falciparum malaria except the Dominican Republic, Haiti, countries in Central America west of the Panama Canal Zone, Egypt, and most countries in the Middle East .

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    The toxic effects on the cardiovascular system tend to be more severe from chloroquine than quinine. Toxicity on the eye oculotoxicity is the major problem from quinine poisoning. The side effects of pharmacological treatment with quinine are common and become exaggerated when the patient has taken a toxic dose Nausea and vomiting, Deafness. The most important measures after a diagnosis of chloroquine poisoning are immediate intubation so that diazepam 1 mg/kg can be administered intravenously as specific antidote without danger of. Retina Manifestations of Chloroquine and Hydroxychloroquine Toxicity. The classical definition of chloroquine toxicity is characterized by bilateral pigmentary change of the macula usually sparing the fovea. This has come to be known as bull’s-eye maculopathy. The retinal periphery may also be involved but infrequently.

    Chemoprophylaxis should begin 1 to 2 weeks before arrival in the endemic area, allowing time for development of adequate blood concentration of the chemoprophylactic agent and evaluation of any adverse reactions (see General Dosing Information ) . In addition, resistance to both chloroquine and the sulfadoxine and pyrimethamine combination is widespread in Thailand, Myanmar, Cambodia, and the Amazon basin area of South America; resistance also has been reported sporadically in sub-Saharan Africa .

    Treatment of severe chloroquine poisoning

    Treatment of hydroxychloroquine overdose - ScienceDirect, PDF Chloroquine poisoning - ResearchGate

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  6. Quinine and chloroquine poisoning are characterized by severe cardiovascular toxicity resulting from sodium and potassium channel blockade, leading to hypotension, shock, arrhythmias and cardiac arrest. Quinine poisoning can cause irreversible visual loss. Severity of symptoms is closely related to the ingested dose and plasma concentration. Single-dose activated charcoal can be given within 1.

    • Quinine and chloroquine - Medicine.
    • Hydroxchloroquine and Chloroquine Toxicity.
    • Survival after Massive Hydroxychloroquine Overdose.

    Chloroquine-induced itching is very common among black Africans 70%, but much less common in other races. It increases with age, and is so severe as to stop compliance with drug therapy. It is increased during malaria fever; its severity is correlated to the malaria parasite load in blood. An overdose of chloroquine can be fatal, especially in children. Chloroquine overdose must be treated quickly. You may be told to induce vomiting right away at home, before transport to an emergency room. Ask the poison control center how to induce vomiting in the case of an overdose. It is preferable that treatment for malaria should not be initiated until the diagnosis has been established by laboratory investigations. “Presumptive treatment” without the benefit of laboratory confirmation should be reserved for extreme circumstances strong clinical suspicion or severe disease in a setting where prompt laboratory diagnosis is not available.

  7. Bazalai XenForo Moderator

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  8. peterpro Guest

    Aralen - FDA prescribing information, side effects and uses Aralen, chloroquine phosphate, USP, is a 4-aminoquinoline compound for oral administration. It is a white, odorless, bitter tasting, crystalline substance, freely soluble in water. Aralen is an antimalarial and amebicidal drug.

    Chloroquine Hydrochloride C18H28Cl3N3 ChemSpider
  9. Robertt Moderator

    Infections with Plaquenil? DailyStrength I thought plaquenil did not lower the immune system as badly as immonosuppressants and steroids, yet here I am a couple of weeks into it and I have a bad throat infection. Think I should hold off on taking it until I see the doctor on Monday, like I had to do with immunosuppressants? Or should I.

    Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses