What is chloroquine resistance

Discussion in 'Chloroquine Online' started by ksar7, 11-Mar-2020.

  1. MaxuS New Member

    What is chloroquine resistance


    Parasites that cause malaria typically enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia.

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    Chloroquine phosphate comes as a tablet to take by mouth. For prevention of malaria in adults, one dose is usually taken once a week on exactly the same day of the week. Your doctor will tell you how many tablets to take for each dose. One dose is taken beginning 2 weeks before traveling to an area. Effects of chloroquine? Chloroquine is a relatively well-tolerated. medicine. The most common adverse reactions reported are stomach pain, nausea, vomiting, and headache. These side effects can often be lessened by taking chloroquine with food. Chloroquine may also cause itching in some people. All medicines may have some side effects. Chloroquine A drug used in the treatment of MALARIA, RHEUMATOID ARTHRITIS and lupus erythematosus. In 1993 the clinical effectiveness of chloroquine in Malawi was less than 50 percent and it was replaced by sulfadoxine and pyrimethamine. But ten years late the efficiency had risen again to 99 percent. The drug is on the WHO official list. Brand names are Avoclor and Nivaquine.

    Chloroquine is also used to treat amebiasis (infection caused by amoebae). Chloroquine is used to treat and to prevent malaria.

    What is chloroquine resistance

    Lack of Evidence for Chloroquine-Resistant Plasmodium falciparum., Medicines for the Prevention of Malaria While Traveling - Chloroquine.

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  6. Dec 10, 2019 Chloroquine is an antimalarial drug. Doctors can usually cure people who are infected with the malaria parasite with various drugs, including this one, but sometimes the parasite is immune to a certain drug. In the case of chloroquine resistance, the parasite appears to have evolved in a way.

    • What Is Chloroquine Resistance? with picture.
    • Chloroquine definition of chloroquine by Medical dictionary.
    • Chloroquine drug Britannica.

    Resistance to chloroquine of malaria strains is known to be associated with a parasite protein named PfCRT, the mutated form of which is able to reduce chloroquine accumulation in the digestive vacuole of the pathogen. Chloroquine-resistant P. falciparum first developed independently in three to four areas in Southeast Asia, Oceania, and South America in the late 1950s and early 1960s. Since then, chloroquine resistance has spread to nearly all areas of the world where falciparum malaria is transmitted. Chloroquine became the drug of first choice in malaria therapy for more than two decades until resistance limited the use of the drug. The resistance is correlated to point mutations in the gene pfcrt 26. The gene codes for a transporter PfCRT.

     
  7. f3d0r0v New Member

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  8. SuperOK User

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  9. drygb Guest

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  10. juicy_emad XenForo Moderator

    Chloroquine and/or Proguanil - Fit for Travel Chloroquine is very toxic in overdose - parents must take special care to store the tablets safely. It is generally accepted, as a result of long usage, to be safe in pregnancy. Proguanil. Patient Information Leaflet PIL for proguanil. Licensed for prophylaxis in UK. Preparations available Paludrine® Zeneca. Adult dose is 200mg daily.

    Malaria - Chapter 4 - 2020 Yellow Book Travelers' Health CDC