Chloroquine and malaria

Discussion in 'Chloroquine Phosphate 500 Mg' started by Creativa, 06-Mar-2020.

  1. horn d kounin Well-Known Member

    Chloroquine and malaria


    For decades, the drug was a front-line treatment and prophylactic for malaria. In a three-page paper published Tuesday in Cell Research, scientists at the Wuhan Institute of Virology’s State Key Laboratory of Virology write that both chloroquine and the antiviral remdesivir were, individually, “highly effective” at inhibiting replication of the novel coronavirus in cell culture.

    Hydroxychloroquine renal toxicity Chloroquine in chikungunya Chloroquine dosing in infants

    A blockchain investor named James Todaro tweeted that an 85-year-old malaria drug called chloroquine was a potential treatment and preventative against the disease caused by the new coronavirus. The former may simulate an attack of cerebral malaria. When the diagnosis is in doubt the urine should be tested for porphobilinogen. Where self-medication is common and chloroquine is used without supervision to treat virtually any febrile condition, chloroquine abuse has been claimed to be a common cause of cardiac atrio-ventricular block. Chloroquine is the generic form of the brand-name prescription medicine Aralen, which is used to prevent and treat malaria — a mosquito-borne disease caused by a parasite — and to treat amebiasis, an infection of the intestines caused by a parasite.

    “It’s interesting in that it really lacks a lot of details but, nevertheless, if you look at the data as presented, at least in vitro, it seems like chloroquine can be used as an early-stage drug,” he said. Their drug screen evaluated five other drugs that were not effective. Though the paper is brief, John Lednicky, a professor at the University of Florida’s Emerging Pathogens Institute, found its results intriguing.

    Chloroquine and malaria

    Chloroquine Oral Route Proper Use - Mayo Clinic, WHO Model Prescribing Information Drugs Used in Parasitic Diseases.

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  6. Commonly used on holidays in malaria prone destinations, chloroquine and hydroxychloroquine will not be over familiar to the emergency physician. However, it is one of the leading causes of drug overdose in malaria prone countries and also the occasional toddler has managed to consume the grandparents lupus or rheumatoid arthritis medication leading to lethal consequences.

    • Chloroquine and Hydroxychloroquine • LITFL • Toxicology Library Toxicants.
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    Areas with chloroquine-sensitive malaria include many Latin American countries where there is predominantly P. vivax malaria. Chloroquine-sensitive P. falciparum is present in the Caribbean and Central American countries west of the Panama Canal. For destinations where chloroquine-sensitive malaria is present, in addition to mosquito avoidance measures, the many effective prophylaxis options include chloroquine, atovaquone-proguanil, doxycycline, mefloquine, and tafenoquine. Aside from preventing and treating malaria, chloroquine is also occasionally used for amebiasis that is occurring outside the intestines, rheumatoid arthritis, and lupus erythematosus. The drug is chloroquine, a widely prescribed anti-malaria pill that was first approved in the US in 1949. Early laboratory research and anecdotal reports about using it for people with COVID-19.

     
  7. YaZzzz NeOFF Guest

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  8. reddiprus New Member

    ARALEN CHLOROQUINE PHOSPHATE, USP Label ARALEN ® CHLOROQUINE PHOSPHATE, USP For Malaria and Extraintestinal Amebiasis DESCRIPTION ARALEN, chloroquine phosphate, USP, is a 4-aminoquinoline compound for oral administration. It is a white, odorless, bitter tasting, crystalline substance, freely soluble in water. ARALEN is an antimalarial and amebicidal drug.

    Chloroquine - LiverTox - NCBI Bookshelf
     
  9. korall XenForo Moderator

    Chloroquine for Treatment of Glioblastoma Multiforme RxWiki Chloroquine as Adjuvant to the Treatment of Glioblastoma Multiforme, A Randomized Trial Brief Summary Chloroquine is a strong lysosomotropic and DNA-intercalating agent in experimental studies

    This Malaria Drug Is Having an Amazing Effect on Brain.