Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take hydroxychloroquine with all of your drugs and health problems. Nurse teaching to a patient taking hydroxychloroquine Are there any withdrawal symptoms from plaquenil Lupus skin rash is the most common complaint among Lupus patients. And the Lupus skin rash treatments that actually work are too few and far in between. Lupus skin rash was once the worst symptom for me. As a woman in her 20’s just diagnosed with lupus, I was desperate to look not only normal but cared a lot about looking good. While skin is damp, apply moisturizing lotion. Apply over-the-counter 1 percent hydrocortisone cream twice daily to calm redness, itching, and swelling. People with RA face an increased risk of infection, so if you have a widespread, blistering sunburn, seek medical help, and do not scratch. Re Plaquenil and Sun Exposure Reply #13 on June 12, 2011, AM After a long dark winter of seeing no sun, I finally went into the sun for an hour, early in the morning, and over the next day, developed a red raised rash on all exposed parts, a rash that lasted for several weeks. For all uses of hydroxychloroquine: WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Do not start, stop, or change the dose of any drug without checking with your doctor. Plaquenil and sun rash Plaquenil and the sun - Sarcoidosis - Inspire, Rheumatoid Arthritis Medication Beware of Sunburn if You. Chloroquine 750 mg This can trigger symptoms such as skin rashes, itching, and burning. Excess sun exposure can also cause flares in systemic lupus, triggering symptoms such as joint pain, weakness, and fatigue. Lupus and Sun Exposure. Plaquenil and Sun Exposure - Sjogren's World. Will you have Photosensitivity reaction with Plaquenil.. Rash from a phototoxic reaction is mainly confined to the sun-exposed area of the skin. A phototoxic reaction typically clears up once the drug is discontinued and has been cleared from the body, even after re-exposure to light. Plaquenil is a slow-acting drug, meaning that it can take up to 6 months to experience the full benefits of this medication, but it is possible for symptoms to improve in as few as 1 or 2 months. Plaquenil and other antimalarials are the key to controlling lupus long-term, and some lupus patients may be on Plaquenil for the rest of their lives. Plaquenil has beneficial effects on 3 major aspects of lupus; skin rashes, aches & pains and fatigue. It has also been found to help in a number of other features of the disease, though less predictably. It is very effective in the treatment of a whole variety of lupus skin rashes, particularly those found to be worsened by sunlight.