One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine (Plaquenil), a chloroquine derivative. It is used to treat many diseases including malaria, rheumatoid arthritis and systemic lupus erythematosus. Hydroxychloroquine and acetaminophen Plaquenil not working Chloroquine derived from Pharmacokinetics Following a single 200 mg oral dose of PLAQUENIL to healthy male volunteers, the mean peak blood concentration of hydroxychloroquine was 129.6 ng/mL, reached in 3.26 hours with a half-life of 537 hours 22.4 daysthe same study, the plasma peak concentration was 50.3 ng/mL reached in 3.74 hours with a half-life of 2963 hours 123.5 days. SIDE EFFECTS. The following adverse reactions have been identified during post-approval use of PLAQUENIL or other 4-aminoqunoline compounds. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. Plaquenil and Flatulence - from FDA reports Summary Flatulence is found among people who take Plaquenil, especially for people who are female, 60+ old, have been taking the drug for 5 - 10 years, also take medication Folic Acid, and have Arthritis. How severe was Flatulence and when was it recovered Flatulence in Plaquenil; It is imperative that patients and physicians are aware of and watch for this drug’s ocular side effects. Retinal toxicity from hydroxychloroquine is rare, but even if the medication is discontinued, vision loss may be irreversible and may continue to progress. Plaquenil ful fiel derg severe Immune & Autoimmune - Lupus Plaquenil Depletes Vit D., Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses Plaquenil compared to quininePlaquenil and radiation PLAQUENIL hydroxychloroquine sulfate tablets contain 200 mg hydroxychloroquine sulfate. patients of Asian descent, it is recommended that visual field testing be performed in the central 24 degrees instead of the central 10 degrees. PLAQUENIL has been shown to cause severe hypoglycemia including loss of PLAQUENIL HYDROXYCHLOROQUINE SULFATE TABLETS, USP DESCRIPTION. Will you have Flatulence with Plaquenil - eHealthMe. Plaquenil What You Need to Know - Kaleidoscope Fighting Lupus. Hydroxychloroquine side effects may range from mild to severe, although some side effects may go away with time. but my eye doctor does make me go in 2 times a year for visual field exams. My eye doctors father has Lupus so he has lots of empathy and gives great care.”. “I have been on the Plaquenil a little over a month at the full. Tell your doctor immediately if any of these rare but very serious side effects occur severe stomach/abdominal pain, severe nausea/vomiting, easy bleeding/bruising, signs of infection e.g. fever, persistent sore throat, seizures, shortness of breath, swelling ankles/feet, extreme tiredness, dark urine, yellowing eyes/skin. I see my doc in 5 days and rather than do the full 800mg. I'm weaning myself off, before I become suicidal I already want to hurt myself, I'm so depressed, but not suicidal yet. I would recommend Plaquenil for people without or with only mild depressive disorders, but not to someone like me with severe, disabling bipolar disorder.