Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Chloroquine cyanosis Rashes due to hydroxychloroquine Chloroquine retinal screening Lower back or side pain; noisy breathing; painful or difficult urination; red irritated eyes; red skin lesions, often with a purple center; severe mood or mental changes; sore throat sores, ulcers, or white spots on the lips or in the mouth; sticking out of the tongue; stomach pain; swelling of the feet or lower legs; swollen or painful glands Anti-malarial medications have shown to improve muscle and joint pain, skin rashes, pericarditis, and other lupus symptoms such as fatigue and fever. such as the kidney and central nervous system your brain and spinal cord and may help to reduce flares by as much as 50%. Plaquenil and other anti-malarials are the key to controlling lupus. I have been on Plaquenil for years. It has not helped me with fatigue. Things like vitamins and exercise might assist with decreasing the fatigue level. I have been on 2 Dmards and a biologic for the longest time. I also take Tramadol for pain and now Indomethicin has been added to the mix to help with stiffness. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Does plaquenil reduce pain Will you have Back pain with Plaquenil - eHealthMe, Treating Lupus with Anti-Malarial Drugs Johns Hopkins. Chloroquine autophagy cancerPlaquenil eye tests Hydroxychloroquine is a DMARD. The brand name is Plaquenil. What does Plaquenil do? Plaquenil relieves pain and swelling and prevents damage to joints. How long does Plaquenil take to work? Plaquenil works very slowly. In 1 to 3 months you should start to feel better. You may continue to get better for up to 1 year. Lupus Medicines Hydroxychloroquine - Brigham and Women's.. Plaquenil for fatigue and pain DailyStrength. Plaquenil Uses, Dosage & Side Effects -. Plaquenil hydroxychloroquine is an antimalarial medication used to treat or prevent malaria, a disease caused by parasites, which enter the body through the bite of a mosquito. Plaquenil is also used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Plaquenil Hydroxychloroquine belongs to a group of medications known as anti-inflammatories and antimalarials. It is used alone or in combination with other anti-arthritic medications to treat rheumatoid arthritis. It helps to reduce pain, stiffness, and swelling in joints. Plaquenil What You Need to Know. Contents What is Plaquenil. Reduce muscle and joint pain; Reduce lupus related rashes; Protect against pleuritis inflammation of the lining of the lungs. of generic hydroxychloroquine can sometimes cause stomach irritation that usually does not occur with the brand name Plaquenil. Your doctor can make.