It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as lupus, rheumatoid arthritis, and others. Malaria is spread by mosquitoes, which transmit the parasites that cause the infection, usually in tropical and subtropical parts of the world. Chloroquine phosphate 250 mg side effects Hydroxychloroquine 400 mg side effects An African American woman, aged 50 years, presents with painless “bruises” on her leg. She first noticed bruises on both legs a year ago and reports that they have since become larger. Hydroxychloroquine is an antimalarial medication that can cause hyperpigmentation of nails, mucosa, and skin 1–5. Retrospective studies cite the incidence of drug-related hyperpigmentation from hydroxychloroquine to be as high as 33% of individuals. Elder abuse is a cause of significant morbidity and mortality in older individuals 7–9. WebMD's guide to the symptoms of lupus. When you have lupus, something happens to your body’s natural defense system your immune system to make it work incorrectly. Instead of only targeting. For example, it may be combined with an antibiotic to treat chronic Q-fever, which humans usually catch from farm animals or raw milk. Plaquenil is used to treat other types of infections too. Plaquenil induced bruising on shins Hydroxychloroquine-induced pigmentation in patients with., Hydroxychloroquine-Associated Hyperpigmentation. - PubMed Central PMC Obgyn plaquenil lupus Bruises, or contusions, cause skin discoloration, swelling and tenderness. Sprained ankle. An ankle sprain is an injury the ligaments in the foot causing pain, tenderness, swelling, and bruising. Hematoma. A hematoma is a collection of blood in the tissue outside of a damaged blood vessel, usually after an injury. Bruising or discoloration, Swelling and Swelling Common.. Lupus Symptoms Fatigue, Fever, Swollen Lymph Nodes, Rash.. Skin Pigmentation with Hydroxychloroquine Plaquenil — Donovan Hair Clinic. Leukemia is a type of blood cancer that develops in bone marrow, where blood cells are made. The symptoms of leukemia can vary widely, including occasional rashes and bruising on the skin. We. Hydroxychloroquine Plaquenil stimulates the pigment producing cells in the skin called melanocytes. As a result, there is both hemosiderin iron and melanin accumulation in the dermis. The exact reasons why this phenomenon happens is not clear. However, trauma and bruising may faciliate the developement of pigmentation. Note This document contains side effect information about hydroxychloroquine. Some of the dosage forms listed on this page may not apply to the brand name Plaquenil. For the Consumer. Applies to hydroxychloroquine oral tablet. Along with its needed effects, hydroxychloroquine the active ingredient contained in Plaquenil may cause some.