Hydroxychloroquine is available as the brand-name drug Plaquenil. Generic drugs usually cost less than the brand-name version. Hydroxychloroquine may be used as part of a combination therapy. Plaquenil and melatonin The looks of a plaquenil pill Plaquenil pancreatitis Hydroxychloroquine sulfate is a synthetic antimalarial drug which can also inhibit Toll-like receptor 7/9 TLR7/9 signaling. - Mechanism of Action & Protocol. Microbiology –Malaria. Mechanism of action The precise mechanism by which hydroxychloroquine exhibits activity against Plasmodium is not known. Hydroxychloroquine, like chloroquine, is a weak base and may exert its effect by concentrating in the acid vesicles of the parasite and by inhibiting polymerization of heme. Hydroxychloroquine, an alkylated 4-aminoquinoline, is a hydroxylated form of chloroquine and has a biological mechanism of action similar to chloroquine’s. Hydroxychloroquine was originally developed as a safer alternative to chloroquine for the treatment of malaria and was later found to have antirheumatic and anti-inflammatory uses. Hydroxychloroquine is used to treat lupus erythematosus and rheumatoid arthritis. It isn’t fully understood how this drug works to treat lupus erythematosus or rheumatoid arthritis. That means you may need to take it with other drugs. It treats malaria by killing the parasites that cause the disease. Hydroxychloroquine sulphate mechanism of action Hydroxychloroquine Plaquenil Side Effects & Dosage for Malaria, DailyMed - HYDROXYCHLOROQUINE SULFATE tablet Plaquenil for mrsa Hydroxychloroquine is usually taken with food or milk to prevent stomach upset. The dosage and length of treatment are based on your medical condition and response to therapy. In children, dosage. Hydroxychloroquine SULFATE -. Hydroxychloroquine Information for Providers AIDSinfo. Hydroxychloroquine Plaquenil -. Hydroxychloroquine Plaquenil® is a 4-amino-quinoline antimalarial medication that is widely used to treat systemic lupus erythematosus SLE, rheumatoid arthritis, and related inflammatory and dermatological conditions. It is a hydroxylated version of chloroquine, with a similar mechanism of action. However, following an identical dose of. Box 1 Main mechanisms of actions by hydroxychloroquine and chloroquine Hydroxychloroquine and chloroquine can inhibit certain cellular functions and molecular pathways involved in immune. Hydroxychloroquine affects the function of lysozomes in humans as well as plasmodia. 4 Altering the pH of the lysozomes reduces low affinity self antigen presentation in autoimmue diseases and interferes with the ability of plasmodia to proteolyse hemoglobin for their energy requirements. 4 Hydroxychloroquine has a long duration of action as it may be taken on a weekly basis for some indications. 8 Hydroxychloroquine may lead to severe hypoglycemia and so diabetic patients are advised to.