Ongoing monitoring of blood counts, liver and kidney function is also required. Prescribed for Acute Lymphocytic Leukemia, Acute Lymphoblastic Leukemia, Rheumatoid Arthritis, Psoriatic Arthritis, Solid Tumors, Small Cell Lung Cancer, Systemic Sclerosis, Neoplastic Diseases, Trophoblastic Disease, Osteosarcoma, Non-Small Cell Lung Cancer, Non-Hodgkin's Lymphoma, Psoriasis, Mycosis Fungoides, Dermatomyositis, Breast Cancer, Choriocarcinoma, Meningeal Leukemia, Graft-versus-host disease, Head and Neck Cancer, Juvenile Idiopathic Arthritis, Lymphoma. Oral plaquenil Leukemia and plaquenil Plaquenil for sjogren's reviews Does anyone else feel worse on Plaquenil? Support Forums Rheumatoid Arthritis. then I started taking methotrexate as well so I think it's the combo that gave me some mobility back. But I do still have swelling, and dizziness as well. I only take hAlf a pill a day so that might lessen nausea or whatever side effects. maybe Plaquenil too. Hydroxychloroquine is sometimes combined with methotrexate for additive benefits for signs and symptoms or as part of a regimen of “triple therapy” with methotrexate and sulfasalazine. Mechanism The mechanism of action of antimalarials in the treatment of patients with rheumatoid arthritis is unknown but is thought to involve changes in antigen presentation or effects on the innate immune system. Plaquenil vs Methotrexate.sure to know the potential side affects and what monitoring needs to take place. I thought I was told that with Plaquenil you need to monitor your eyes more carefully. With both drugs you would need regular blood tests to monitor various blood counts as well as liver function. " Prednisone effectively controls inflammation and an overactive immune system but may not be suitable for everybody. May also be prescribed off label for Bladder Cancer, Acute Nonlymphocytic Leukemia, Soft Tissue Sarcoma, Scleroderma, Pityriasis rubra pilaris, Pemphigus, Pemphigoid, Pancreatic Cancer, Ovarian Cancer, Mantle Cell Lymphoma, Brain Tumor, Bullous Pemphigoid, Cervical Cancer, Cogan's Syndrome, Colorectal Cancer, Ectopic Pregnancy, Eczema, Esophageal Carcinoma, Gastric Cancer, Hodgkin's Lymphoma, Uveitis. Whichhis worse plaquenil or methotrexate Managing Arthritis in Lupus SLE Workshop Patient Education, Rheumatoid Arthritis Treatment Options Johns Hopkins. Where is sandoz plaquenil produced Sorry to hear that you are having a lot of pain with your RA. I have lupus which mainly affects my joints and skin. I have been taking hydroxychloroquine which is the generic of plaquenil for the past three years. My rheumy recently added Imuran instead of methotrexate. Plaquenil hydroxychloroquine takes up to 3 months to begin working. Which would you pick and why? - Plaquenil or Methotrexate. Arthritis Board Index plaquenil vs methotrexate. How Does Methotrexate Treat Rheumatoid Arthritis? - WebMD. Apr 13, 2005 Methotrexate MTX, an anti-metabolite that inhibits purine pathways, has been the hallmark of standard of care for many years in the treatment of rheumatoid arthritis RA. However, many RA patients continue to have active disease despite maximal doses of methotrexate. The effects of methotrexate and hydroxychloroquine combination therapy vs methotrexate monotherapy. combination treatment was preferentially given to patients with worse RA, so this would result in bias in the conservative direction. which is probably due to treatment intensification in the monotherapy group; 42% started an extra. Plaquenil didn't work for me. Methotrexate isn't so bad if you can deal with being stupidly tired and brain foggy one day a week, a day I dub "Methotrexate Hangover Day.". Start with either, and keep in mind you may have to try a few different meds before you find one that works.