Chloroquine mechanism of action

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  1. slavabuzy XenForo Moderator

    Chloroquine mechanism of action


    It may have both an anti-spirochaete activity and an anti-inflammatory activity, similar to the treatment of rheumatoid arthritis. And caution is required if patients have certain heart conditions, diabetes, psoriasis etc.

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    Study explains malaria origin and presents Plasmodium evolution and chloroquine mode of action on parasite. Hypotheses on the chloroquine resistance mechanism and reversion of antimalarial drug. This finding, obtained without making any assumption on the nature of PfCRT, implies that hypothesis H2 is plausible, regardless of the chloroquine species involved in the chloroquineHM binding and of the mechanism of action of the mutated PfCRT. Consequently, none of the 20 cells C 1–5,1–4 can be shaded at this stage. Chloroquine undergoes appreciable degradation in the body. The main metabolite is desethylchloroquine, which accounts for one fourth of the total material appearing in the urine; bisdesethylchloroquine, a carboxylic acid derivative, and other metabolic products as yet uncharacterized are found in small amounts.

    The most serious adverse effects affect the eye, with dose-related retinopathy as a concern even after hydroxychloroquine use is discontinued. The most common adverse effects are a mild nausea and occasional stomach cramps with mild diarrhea.

    Chloroquine mechanism of action

    On the molecular mechanism of chloroquine's antimalarial action, On the Mechanism of Chloroquine Resistance in Plasmodium.

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  4. The clinical usefulness of chloroquine, and in some recent cases of quinine as well, has been much reduced by the evolution and spread of chloroquine resistant malaria parasites. The mechanism of resistance involves a reduced accumulation of the drug, although again the mechanism involved is controversial.

    • Chloroquine Mechanism of drug action and resistance in..
    • CHLOROQUINE PHOSPHATE, USP.
    • Chloroquine - Wikipedia.

    Its mechanism of action is unknown; however, malarial parasites invade human red blood cells, and chloroquine may prevent malarial parasites from breaking down metabolizing hemoglobin in human red blood cells. Chloroquine resistance is associated with a decrease in the amount of chloroquine that accumulates in the food vacuole, the site of action for chloroquine. The mechanism for this decreased accumulation is controversial. Some studies have shown that the decrease in drug accumulation is due to an increase in drug efflux. Inhibition of DNA replication is proposed as a general mechanism of the antimicrobial action of chloroquine. The drug chloroquine is bactericidal for Bacillus megaterium ; it inhibits DNA and RNA biosynthesis and produces rapid degradation of ribosomes and dissimilation of ribosomal RNA.

     
  5. SANSAN User

    In 20, no local mosquito-borne Zika virus transmission has been reported in the continental United States. Chloroquine, an Endocytosis Blocking Agent, Inhibits Zika. Anti-malaria drug being tested for efficacy against COVID-19 Chloroquine, a FDA-approved Drug, Prevents Zika Virus.
     
  6. Snord Moderator

    The Risk of Retinal Toxicity with Plaquenil - Sjogren's The side effect that is of greatest concern is retinal toxicity. Retinal toxicity of Plaquenil may manifest itself with subtle disturbances of the retinal pigment epithelium which may eventually lead to complete destruction of the macula in the form of bull’s-eye maculopathy.

    Plaquenil Side Effects on Your Eyes and Vision