In Sjögren’s, Plaquenil is used to treat many symptoms of Sjögren’s including fatigue, joint symptoms of arthritis and arthralgias (joint pain), dry mouth and dry eyes. Similar to its use in systemic lupus erythematosus, many clinicians feel that it is useful in reducing general Sjögren’s “disease activity.” One of the reasons that physicians feel comfortable in prescribing Plaquenil is its low risk to benefit ratio. Chloroquine eye toxicity Taking two plaquenil instead of 1.5 Plaquenil for weight loss Chloroquine overdose death Jun 20, 2019 Fundus camera Optos Description Ultra-wide field fundus autofluorescence photograph of a 60-year-old female with plaquenil toxicity affecting both eyes. Patient was taking plaquenil for management of Lupus, but discontinued use in 2011, but continues to be affected with severe progression of toxicity. Fundus autofluorescence FAF is a non-invasive retinal imaging modality used in clinical practice to provide a density map of lipofuscin, the predominant ocular fluorophore, in the retinal pigment epithelium. Multiple commercially available imaging systems, including the fundus camera, the confocal scanning laser ophthalmoscope, and the ultra-widefield imaging device, are available to the. Aug 06, 2014 Hydroxychloroquine, sold under the brand name Plaquenil Sanofi-Aventis, is an antimalarial drug that has gained widespread use in treating various autoimmune diseases, including systemic lupus erythematosus and rheumatoid arthritis. 1 By some estimates, more than 150,000 patients are on long-term therapy with this medication in America alone. 2 Retinal toxicity associated with HCQ use is. As with any medication, allergic reactions including skin rashes and non-allergic reactions can occur. This means that the side effects of Plaquenil are mild and infrequent compared with its potential benefits. Plaquenil toxicity fundus autofluorescence Early Plaquenil Toxicity Detected without Bull’s Eye., Clinical applications of fundus autofluorescence in retinal. Plaquenil retina damagePlaquenil sister drugPlaquenil nursing interventions Although multifocal electroretinogram mfERG and fundus autofluorescence FAF are not currently primary tests used in the evaluation of Plaquenil retinal toxicity, they may be beneficial when the diagnosis or findings are enigmatic or an adjunct test is warranted. How to Succeed in Plaquenil Screenings. Multimodal Imaging in Plaquenil Toxicity. The Risk of Retinal Toxicity with Plaquenil. Ultra-widefield fundus autofluorescence images placed in order of severity in the eyes with hydroxychloroquine retinopathy with a parafoveal dominance pattern. Retinopathy varies from ring-shaped parafoveal hyperautofluorescence to round macular hypoautofluorescence and finally to bull's eye maculopathy with peripheral involvement rightmost. Today it is recommended that every single person on Plaquenil get a visual field 10-2 test, plus one of the three other highly sensitive screening tests the FAF fundus autofluorescence imaging, the SD-OCT spectral domain optical coherence, or the multifocal electroretinogram mfERG,” Thomas says. The Nuts and Bolts of Fundus Autofluorescence Imaging. also helpful in screening for medication toxicity, including eye problems related to hydroxychloroquine.