Acute chloroquine poisoning

Discussion in 'Generic Chloroquine Online' started by edula, 15-Mar-2020.

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    Acute chloroquine poisoning


    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

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    Each tablet contains 500 mg of Chloroquine phosphate USP, equivalent to 300 mg Chloroquine base. Inactive Ingredients colloidal silicon dioxide, dibasic calcium phosphate, hydroxypropylmethylcellulose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, polysorbate80, pregelatinized starch. Acute chloroquine intoxication is responsible for a hypokalaemia which correlates with the gravity of the intoxication and may be due to a transport-dependent mechanism. Plasma potassium concentrations should be carefully observed, particularly among patients who also receive catecholamine infusions. SummaryLarge doses of chloroquine can cause poisoning. Our aim was to determine the possible relation between the plasma potassium concentration on admission with the severity of acute chloroquine poisoning and to assess the mechanism of chloroquine-induced conducted a retrospective study of 191 consecutive cases. The main data included the occurrence of vomiting before.

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    Acute chloroquine poisoning

    Quinine and chloroquine - ScienceDirect, Hypokalaemia related to acute chloroquine ingestion.

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  5. A retrospective study was carried out, over a twelve year period, of all cases of acute chloroquine poisoning where more than 2 g of chloroquine had been taken. It included 386 patients; of these, 60 who had taken drugs other than chloroquine, and 17 who had ingested less than 1 g of the drug, were excluded.

    • Chloroquine C18H26ClN3 - PubChem.
    • Hypokalaemia related to acute chloroquine ingestion - The..
    • Recommendations on Screening for Chloroquine and..

    Chloroquine causes rare but life-threatening toxicity. The prognostic value of plasma chloroquine concentrations in acute poisonings remains poorly investigated. We investigated the hypothesis that blood chloroquine concentrations better predicted chloroquine poisoning severity than plasma concentrations. Oct 19, 1996 Acute chloroquine intoxication is responsible for grave cardiovascular disturbances which may be rapidly life-threatening. For this reason, any suspicion of acute chloroquine intoxication requires hospitalisation in an intensive care unit for a minimum of 12 hours. Case 2 was complicated by the absence of a helpful history and only the previous experience of acute pulmonary oedema associated with a story of a visit to a malarial district in the recent past raised the possibility of acute chloroquine poisoning.

     
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