Chloroquine lysosomal membrane permeabilization

Discussion in 'Hydroxychloroquine 200 Mg Tab' started by Mz?, 26-Feb-2020.

  1. Grankin XenForo Moderator

    Chloroquine lysosomal membrane permeabilization


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    Nov 02, 2018 Chloroquine is a lysosomotropic agent that triggers destabilization of the lysosomal membrane in various tumor cells. In one study chloroquine was used to restore sensitivity to cisplatin in refractory non-small-cell lung cancer cells 82. Autophagy and lysosomal cholesterol and permeabilization assays Primary mouse hepatocytes PMH were incubated with rapamycin 2µM with or without chloroquine 50µM to examine autophagic flux. In some cases, PMH were incubated with chloroquine and brefeldinA to block autophagy and examine the impact on of ER stress. To investigate the mechanisms of lysosomal cell death, we characterized the cytotoxic action of two widely used quinolone antibiotics ciprofloxacin CPX or norfloxacin NFX. CPX or NFX plus UV light NFX* induce lysosomal membrane permeabilization LMP, as detected by the release of cathepsins from lysosomes.

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    Chloroquine lysosomal membrane permeabilization

    PDF Modulating lysosomal function through lysosome membrane., ASMASE REGULATES AUTOPHAGY AND LYSOSOMAL MEMBRANE PERMEABILIZATION AND.

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  5. Normal lysosomal degradation function is crucial to maintain cellular homeostasis and enable cell survival in the physiological state. Due to its high hydrolase content, lysosomes are potentially harmful to the cell when damage occurs to the lysosomal membrane to induce lysosomal membrane permeabilization LMP.

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    May 19, 2003 To investigate the mechanisms of lysosomal cell death, we characterized the cytotoxic action of two widely used quinolone antibiotics ciprofloxacin CPX or norfloxacin NFX. CPX or NFX plus UV light NFX* induce lysosomal membrane permeabilization LMP, as detected by the release of cathepsins from lysosomes. Chloroquine triggers lysosomal membrane permeabilization in A549cisR cells, promoting the release of lysosomal cathepsins into the cytosol. A549Pt A and A549cisR B cells were loaded with FITC. The lysosomotropic drug LD siramesine exerts lysosomal membrane permeabilization LMP and lysosomal leakage, and provokes reactive oxygen species generation via a detergent-like activity 18,19.

     
  6. Jenkapopko Well-Known Member

    Annotation score:5 out of 5 The annotation score provides a heuristic measure of the annotation content of a Uni Prot KB entry or proteome. UpToDate Current progress in antimalarial pharmacotherapy and multi. Discovery of dual function acridones as a new antimalarial.
     
  7. vileshcka New Member

    Hydroxychloroquine Side Effects, Dosage, Uses, and More Hydroxychloroquine Plaquenil is used to treat malaria, lupus, and rheumatoid arthritis. Learn about side effects, warnings, dosage, and more.

    Long-Term Side Effects of Plaquenil for Rheumatoid Arthritis.