This eye toxicity limits long-term use of the drugs. The risk of toxicity is low for individuals without complicating conditions during the first 5 years of treatment using less than 6.5 mg/kg/day of hydroxychloroquine or 3 mg/kg/day of chloroquine, and/or cumulative doses of less than 1000 gram and 460 gram (total dose), respectively. Difference between hydroxychloroquine and chloroquine How long does it take hydroxychloroquine to affectnyour eyea Name for plaquenil eye exam Risk factors for retinopathy normal daily doses range 75-300mg toxicity has been reported with doses of 1200 to 2400 mg/day for 1 to 2 years. Mechanism - Inhibition of retinal enzymes and phototoxicity have been suggested as possible causes of the retinal degeneration. Chloroquine retinopathy, is a form of toxic retinopathy damage of the retina caused by the drugs chloroquine or hydroxychloroquine, which are sometimes used in the treatment of autoimmune disorders such as rheumatoid arthritis and systemic lupus eye toxicity limits long-term use of the drugs. Several factors have been associated with the risk of developing hydroxychloroquine retinopathy. One of the most important appears to be dosage—with debate over whether daily intake vs. cumulative dosage is most significant. The earliest signs of toxicity include bilateral paracentral visual field changes (best detected with a red test object) and a subtle granular depigmentation of the paracentral RPE. Some physicians suggest that lean body weight is more accurate when calculating daily dosage. Hydroxychloroquine retinopathy risk factors Chloroquine and hydroxychloroquine retinopathy-related risk factors in., Chloroquine retinopathy - Wikipedia Spectrum chloroquineWhat if hydroxychloroquine doesn t work Background/Purpose Hydroxychloroquine HCQ is widely used in the treatment of systemic lupus erythematosus SLE, rheumatoid arthritis RA, and other rheumatic diseases. While generally well-tolerated and regarded as one of the safest treatment options for these conditions, the major long-term risk is vision-threatening retinopathy. The risk of retinopathy has been shown to vary by amount. The Risk of Hydroxychloroquine Toxic Retinopathy and Its.. Hydroxychloroquine-Induced Retinal Toxicity - American.. Hydroxychloroquine-induced retinopathy in a 57-year-old woman. Risk for toxicity is least with less than 6.5 mg/kg/day for hydroxychloroquine and 3 mg/kg/day for chloroquine. Patients are at low risk during the first 5 years of treatment. Cumulative use in excess of 250 grams increases the risk for toxic retinopathy. Other risk factors include obesity, kidney or liver disease, older age. The survey focused on physician's hydroxychloroquine screening practices and their knowledge of risk factors for developing hydroxychloroquine retinopathy. Following institutional review board approval, survey results were compared with the PPP guidelines. Revised Recommendations on Screening for Chloroquine and Hydroxychloroquine Retinopathy. It is important to be aware of risk factors including daily dose, cumulative dose. M. F. Marmor, R. E. Carr, M. Easterbook, et al. American Academy of OphthalmologyRecommendations on screening for chloroquine and hydroxychloroquine retinopathy.