Plaquenil retinopathy pathogenesis

Discussion in 'Hydroxychloroquine 200 Mg Tab' started by AndrO, 13-Mar-2020.

  1. Black Max XenForo Moderator

    Plaquenil retinopathy pathogenesis


    One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine (Plaquenil), a chloroquine derivative. It is used to treat many diseases including malaria, rheumatoid arthritis and systemic lupus erythematosus.

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    Hydroxychloroquine HCQ trade name, Plaquenil and chloroquine CQ trade name, Aralen are drugs established in the treatment of autoimmune disease and skin disorders, but are also emerging as a treatment option in oncology and paediatric inflammatory disorders. Practice Essentials. Chloroquine and hydroxychloroquine belong to the quinolone family. Although their therapeutic and toxic doses differ, they are related drugs with similar clinical indications for use and similar manifestations of retinal toxicity. The image below depicts hydroxychloroquine retinopathy. Hydroxychloroquine, sold under the brand name Plaquenil among others, is a medication used for the prevention and treatment of certain types of malaria. Specifically it is used for chloroquine-sensitive malaria. Other uses include treatment of rheumatoid arthritis, lupus, and porphyria cutanea tarda. It is taken by mouth. Common side effects include vomiting, headache, changes in vision and muscle weakness. Severe side effects may include allergic reactions. It does not appear to be safe during

    It is imperative that patients and physicians are aware of and watch for this drug’s ocular side effects. Retinal toxicity from hydroxychloroquine is rare, but even if the medication is discontinued, vision loss may be irreversible and may continue to progress.

    Plaquenil retinopathy pathogenesis

    Common and Rare Side Effects for Plaquenil Oral, Chloroquine and Hydroxychloroquine Toxicity Practice.

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  7. Apr 10, 2019 Plaquenil hydroxychloroquine belongs to a group of medicines called quinolines. Plaquenil is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia.

    • Plaquenil Uses, Dosage & Side Effects -.
    • Hydroxychloroquine - Wikipedia.
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    Aug 30, 2011 Diagnosis Hydroxychloroquine-induced retinal toxicity Discussion. Chloroquine CQ and hydroxychloroquine Plaquenil HCQ have been used for many years, initially for the treatment of malaria but now more commonly for the treatment of inflammatory diseases such as rheumatoid arthritis and lupus 1. It is now considered for new disease applications in diabetes, heart disease and adjunct cancer therapies 2. DR can be divided into 2 stages non-proliferative diabetic retinopathy NPDR and proliferative diabetic retinopathy PDR. NPDR can be further divided into mild, moderate, and severe stages. 1 In general, retinopathy advances from mild nonproliferative abnormalities, characterized by increased numbers of microaneurysms. Use in patients with psoriasis may precipitate a severe attack of psoriasis; use with caution Postmarketing cases of life-threatening and fatal cardiomyopathy reported with use of hydroxychloroquine as well as of chloroquine Irreversible retinal damage observed in some patients who had received hydroxychloroquine sulfate;

     
  8. Gia Well-Known Member

    Chloroquine has long been used in the treatment or prevention of malaria from Plasmodium vivax, P. malariae, excluding the malaria parasite Plasmodium falciparum, for it started to develop widespread resistance to it. Chloroquine phosphate C18H32ClN3O8P2 - PubChem Chloroquine - FDA prescribing information, side effects. Chloroquine Oral Route Proper Use - Mayo Clinic
     
  9. kos333 XenForo Moderator

    Applies to hydroxychloroquine: oral tablet Along with its needed effects, hydroxychloroquine (the active ingredient contained in Plaquenil) may cause some unwanted effects. Plaquenil Hydroxychloroquine - Side Effects, Dosage. Will you have Immunodeficiency disorders with Plaquenil. Do either hydroxychol/Plaquenil put you at. -
     
  10. AmbieNex User

    SAFETY DATA SHEET Page 1 of 5 Hydroxychloroquine sulfate. Revision 11/11/2018 Page 2 of 5 Hydroxychloroquine sulfate SAFETY DATA SHEET Supersedes Revision 07/14/2015 2.3 Causes serious eye irritation. Harmful if swallowed. Material may be irritating to the mucous membranes and upper respiratory tract.

    Hydroxychloroquine sulfate ≥98% HPLC, powder Sigma-Aldrich