What is the genetic cause of chloroquine resistance

Discussion in 'Hydroxychloroquine 200 Mg Tab' started by ecocom, 03-Mar-2020.

  1. Prognat.ru User

    What is the genetic cause of chloroquine resistance

    This medicine is also sometimes given off-label to help the following conditions: Also, let your doctor know if you drink large amounts of alcohol before starting on this medicine. Your doctor will probably want to order frequent tests to check your body's response to chloroquine.

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    Tag chloroquine resistance Drug Resistance Emergence of resistance to antimalarial drugs has become a major hurdle in the successful treatment of the infection, and has contributed significantly to global malaria-related mortality.1 The genetic basis of this phenomenon involves mutation in the gene named pfcrt Plasmodium falciparum chloroquine resistance transporter. The pfcrt gene, located on chromosome 7, encodes a 49 kDa protein PfCRT localized in parasite's food vacuole 47 with 10 predicted transmembrane domains 48. Genetic evidence that RI chloroquine resistance of Plasmodium falciparum is caused by recrudescence of resistant parasites.

    Let your healthcare provider know if your symptoms either don't improve or worsen while taking this medicine. Keep all appointments with your doctor and laboratory.

    What is the genetic cause of chloroquine resistance

    Several alleles of the multidrug-resistance gene are closely., Chloroquine Modes of action of an undervalued drug.

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  5. Plasmodium falciparum chloroquine resistance is a major cause of worldwide increases in malaria mortality and morbidity. Recent laboratory and clinical studies have associated chloroquine resistance with point mutations in the gene pfcrt. However, direct proof of a causal relationship has remained elusive and most models have posited a multigenic basis of resistance.

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    AUS research team has identified a single gene that they believe enables the malaria parasite Plasmodium falciparum to resist the drug chloroquine. Chloroquine was once medicine's most powerful weapon against P falciparum malaria, the most deadly form of the infection which causes more than 1 million deaths a year. But during the past few decades, the relentless spread of chloroquine-resistant. Malaria still poses one of the major threats to human health. Development of effective antimalarial drugs has decreased this threat; however, the emergence of drug-resistant Plasmodium falciparum, a cause of Malaria, is disconcerting. The antimalarial drug chloroquine has been effectively used, but resistant parasites have spread worldwide. A large part of the answer appears to be a requirement for multiple mutations in the gene responsible for chloroquine resistance. This gene, pfcrt was identified recently in the single chromosomal segment that associated perfectly with the inheritance of chloroquine resistance in a P. falciparum laboratory cross.

  6. Nick Sneer New Member

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