The recurrent, painful tightening usually occurs in the calf muscles and can cause severe insomnia. The exact mechanism is unknown, but the cramps are probably caused by muscle fatigue and nerve dysfunction rather than electrolyte or other abnormalities. Reactions to plaquenil Pain relief from plaquenil Plaquenil use for sjogrens syndrome A low platelet count is a blood disorder that can sometimes be serious. This article looks at platelets and their role within the body. Find out about the many possible causes of a low count. Restless leg syndrome RLS can be confused with leg cramps, but they are 2 distinct conditions. 5 RLS is a neurologic movement disorder that causes limb sensations in which a person exhibits an uncontrollable urge to move the legs and is often associated with disruptions in sleep. 5 Like RLS, leg cramps may have a circadian pattern and. Pressure on the central nerve in the wrist causes a condition called carpal tunnel syndrome. It is characterized by tingling, numbness, and pain in the fingers, which sometimes affects the entire hand. A number of medical conditions, including lupus, can cause carpal tunnel syndrome. Medications that are strongly associated with leg cramps include intravenous iron sucrose, conjugated estrogens, raloxifene, naproxen, and teriparatide. Nocturnal leg cramps are associated with vascular disease, lumbar canal stenosis, cirrhosis, hemodialysis, pregnancy, and other medical conditions. Does plaquenil cause leg cramps Lupus Cramps Dr Garys Lupus Treatment System Cure & Relief, Leg Cramps A Sign of Underlying Illness? Dosage of plaquenil for sjogren& 39Hydroxychloroquine birth defectsHydroxychloroquine visionPlaquenil taper Hydroxychloroquine may cause some people to be agitated, irritable, or display other abnormal behaviors. It may also cause some people to have suicidal thoughts and tendencies, or to become more depressed. If you or your caregiver notice any of these side effects, tell your doctor right away. This medicine may cause hypoglycemia low blood sugar. Hydroxychloroquine Oral Route Side Effects - Mayo Clinic. How Lupus Affects the Muscles, Tendons and Joints Lupus.. Severe Leg Cramps" Rheumatoid Arthritis Community.. It is an unfortunate reality that many important medicines can cause annoying or painful side effects. The medications with a high risk of causing leg cramps are certain asthma medications and diuretics, but countless others can have muscle twitches and spasms as even a low-risk side effect. In rare cases, Plaquenil can cause cardiomyopathy, a chronic disease of the heart muscle. If you're taking Plaquenil for an autoimmune condition, your symptoms should begin to improve after a few. She started me on the generic version of Plaquenil at 200 mg. I have had a really hard time on this medicine. I have had extreme nausea, diarrhea, stomach cramps, and intense vertigo. I began taking it on Thanksgiving day and still experience these side effects. A week ago I asked if there was anything we could do and she stated that this was t.