Yesterday my rheumatologist started me on hydroxychloroquine as well. Is anyone else on this combination and have you had any problems with it as I know hydroxychloroquine can cause eye sight problems. Plaquenil pregnancy Dosing of aralen Plaquenil kills With Plaquenil, the possibility of permanent vision damage scares me. I also want to be sure that I'm taking a drug that will slow/stop the progression of the disease. I've read elsewhere that Plaquenil is not as strong/effective in the treatment of early RA. With Methotrexate, the reports of nausea and possible liver damage are concerning. Combination Therapy with Methotrexate and Hydroxychloroquine for Rheumatoid Arthritis Increases Exposure to Methotrexate SAMANTHA J. CARMICHAEL, JOANNE BEAL, RICHARD O. DAY, and SUSAN E. TETT. If patients did not go into remission after four months, they were randomized either to a combination of multiple DMARDS and low-dose prednisone arm 1 or to adalimumab ADA and methotrexate arm 2. Arm 1 involved 25 mg/wk MTX, 400 mg/day hydroxychloroquine, 2000mg/day sulphasalazine, and 7.5 mg/day of prednisone. Recently my eyes have felt sore and, after posting a question on this site, I am seeing my GP on Monday. Thanks Hi Catjones I have been taking this combination, started on both of them in January this year. Combination methotrexate and plaquenil PATIENT FACT SHEET Hydroxychloroquine Plaquenil, Combination Therapy with Methotrexate and Hydroxychloroquine. Plaquenil maculaChloroquine phosphate flukesChloroquine lysosome inhibitor mechanismPlaquenil for sarcoidosis Plaquenil hydroxychloroquine is an effective medication for autoimmune conditions and malaria that comes with less side effects than other DMARDs. Otrexup methotrexate is the first-choice treatment for many types of cancer and arthritis, but it has many side effects. Compare Plaquenil vs Methotrexate -. Study Shows Methotrexate and Prednisone Combination Therapy.. Does anyone take methotrexate and hydroxychloroquine. - NRAS. Original Article from The New England Journal of Medicine — Treatment of Rheumatoid Arthritis with Methotrexate Alone, Sulfasalazine and Hydroxychloroquine, or a Combination of All Three Medications Compare Methotrexate vs Plaquenil head-to-head with other drugs for uses, ratings, cost, side effects, interactions and more. Methotrexate rated 6.7/10 vs Plaquenil rated 6.8/10 in overall patient satisfaction. Hydroxychloroquine may be used as part of a combination therapy. That means you may need to take it with other drugs. Taking methotrexate with hydroxychloroquine has not been studied. It may.