She suffered from Sjogren syndrome and inflammatory arthritis and was currently treated with prednisone and methotrexate. She was previously treated with hydroxychloroquine (Plaquenil) 200mg bid (6.5mg/kg) for 10 years, which was stopped one year prior to presentation. Hydroxychloroquine fda package insert Medication for rheumatoid arthritis plaquenil Chloroquine autophagy sigma With Plaquenil Plaquenil is manufactured in only a 200 mg tablet The typical dosage is either 200 or 400 mg per day 200 mg daily puts anyone under 68 pounds at risk1 400 mg of Plaquenil daily puts anyone under 135 pounds at a higher risk for toxicity Therefore, 200mg of Plaquenil daily is going to be a safe dosage for virtually all adults13 Chen E, Brown DM, Benz MS, et al. Spectral domain optical coherence tomography as an effective screening test for hydroxychloroquine retinopathy the “flying saucer” sign. Clin Ophthalmol. 2010;51-115821060664PubMed Google Scholar Crossref Apr 10, 2019 Plaquenil hydroxychloroquine belongs to a group of medicines called quinolines. Plaquenil is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. Review of systems: Blurred vision, halos, dry eye, dry mouth, gastroesophageal reflux, joint pain Pupils: Reactive to light in each eye from 5 mm in the dark to 2 mm in the light. Extraocular movements: Full, both eyes (OU) Confrontation visual fields: Full OU Intra-ocular pressure The optic nerves appeared healthy with a 0.3 cup-to-disc ratio. Past Ocular History: None Medical History: Sjogren syndrome and inflammatory arthritis, supraventricular tachycardia, anxiety, depression, peptic ulcer disease Medications: prednisone, methotrexate, amitriptyline, ranitidine, estradiol, tizanidine, diltiazem, Restasis Allergies: codeine, droperidol Family History: heart disease, arthritis, cancer Social History: occasional alcohol but no tobacco or intravenous drug use. Plaquenil oct flying saucer Hydroxychloroquine toxicity - EyeWiki, Comparison of Screening Procedures in Hydroxychloroquine Toxicity Hydroxychloroquine sulfate bp csrPlaquenil co kontrolowacChloroquine 250 mg tabletsChloroquine failure deaths in africaDosage of plaquenil for sjogren& 39 A PubMed search with “flying saucer” as keyword only produced 2 articles.4, 5 In 25 patients treated with HCQ, Chen et al. 4 found toxicity in 5 20%, 2 patients with advanced toxicity and a further 3 with early toxicity, or exhibiting the flying saucer sign 12%. SD-OCT could detect abnormalities before becoming obvious in ocular fundus. SD-OCT as screening test for hydroxychloroquine retinopathy.. Plaquenil Uses, Dosage & Side Effects -. Expanded spectral domain-OCT findings in the early detection.. Chen, Eric. Brown, David M. Benz, Matthew S. Spectral domain optical coherence tomography as an effective screening test for hydroxychloroquine retinopathy the “flying saucer” sign. Clinical Ophthalmology Oct 4 2010. Oct 21, 2010 In the five patients with SD OCT abnormalities, 3 had signs of early HCQ retinopathy while 2 had advanced changes. The “flying saucer” sign was present in all three of the five patients who presented with early HCQ retinopathy. Two patients presented with advanced HCQ retinopathy and moderate to severe vision loss. V. M. Asensio-Sánchez, SD-OCT as screening test for hydroxychloroquine retinopathy The “flying saucer” sign, Archivos de la Sociedad Española de Oftalmología English Edition, 90, 7, 338, 2015.