Malaria is common in areas such as Africa, South America, and Southern Asia. This medicine is not effective against all strains of malaria. Plaquenil and cancer Hydroxy-chloroquine 200 mg without prescription Plaquenil red spots Rheumatoid Arthritis. The action of hydroxychloroquine is cumulative and may require weeks to months to achieve the maximum therapeutic effect see CLINICAL PHARMACOLOGY. Initial adult dosage 400 mg to 600 mg 310 to 465 mg base daily, administered as a single daily dose or in two divided doses. How to use Hydroxychloroquine SULFATE. Hydroxychloroquine is usually taken with food or milk to prevent stomach upset. The dosage and length of treatment are based on your medical condition and response to therapy. In children, dosage is also based on weight. Other Interactions. Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco. Hydroxychloroquine may also be used for purposes not listed in this medication guide. Hydroxychloroquine is also used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Hydroxychloroquine interactions with alcohol HYDROXYCHLOROQUINE SULFATE Food, Alcohol, Supplements and., Hydroxychloroquine Oral Uses, Side Effects, Interactions. Plaquenil and positive ana numbers increasingBrand name plaquenil costPlaquenil macular toxicity Additional AEs known to be associated with hydroxychloroquine are described in the FDA-approved Full Prescribing Information for Plaquenil. 9. Drug Interactions. Hydroxychloroquine is metabolized in the liver, primarily by CYP2C8 and CYP3A4 enzymes. Drugs that inhibit CYP3A4 enzymes may increase plasma levels of hydroxychloroquine. Hydroxychloroquine Information for Providers AIDSinfo. Hydroxychloroquine Oral Route Before Using - Mayo Clinic. Hydroxychloroquine Side Effects, Dosage, Uses, and More. CYP2D6 inhibitors, such as hydroxychloroquine, could theoretically impair propranolol metabolism; the clinical significance of such interactions is unknown. Hydrocodone Moderate Concomitant use of hydrocodone with hydroxychloroquine may increase hydrocodone plasma concentrations and prolong opioid adverse reactions, including hypotension, respiratory depression, profound sedation, coma, and death. Hydroxychloroquine sulfate sulfate base, and are for oral PLAQUENIL® HYDROXYCHLOROQUINE SULFATE TABLETS, USP DESCRIPTION PLAQUENIL h. ydroxychloroquine sulfate is a. white or practically white, crystalline. powder freely. soluble in water; practically insoluble in alcohol, chloroform, and in ether. The. chemical. name for Drug Information. Hydroxychloroquine is used to prevent and treat acute attacks of malaria and to treat both acute and chronic rheumatoid arthritis and lupus. It is in a class of drugs known as antimalarials.