Hydroxychloroquine is available as the brand-name drug Plaquenil. Generic drugs usually cost less than the brand-name version. Hydroxychloroquine may be used as part of a combination therapy. Chloroquine slideshare Hydroxychloroquine not working Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. When used for malaria, Plaquenil hydroxychloroquine appears to be safe for use while breastfeeding. This eMedTV article offers more information on Plaquenil and breastfeeding, and explains whether this drug passes through breast milk. Breastfeeding. Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding. Drug Interactions. Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. Hydroxychloroquine is used to treat lupus erythematosus and rheumatoid arthritis. It isn’t fully understood how this drug works to treat lupus erythematosus or rheumatoid arthritis. That means you may need to take it with other drugs. It treats malaria by killing the parasites that cause the disease. Hydroxychloroquine safe while breastfeeding Hydroxychloroquine use while Breastfeeding, Plaquenil and Breastfeeding - eMedTV Health Information. Chloroquine major issueChloroquine phosphate aquariumWhat is in plaquenil Hydroxychloroquine and chloroquine are excreted into breast milk in small amounts and have been deemed safe by the American Academy of Pediatrics. 1,2 Biologics There is insufficient data for determining the safety of TNF-inhibitors etanercept, infliximab, adalimumab, golimumab, and certolizumab pegol and other biologics, including abatacept, rituximab, anakinra, tofacitinib, and toclizumab, in lactating mothers. 2 Drug Safety in Pregnant & Nursing Women.. Hydroxychloroquine Oral Route Before Using - Mayo Clinic. Precautions and Warnings With Hydroxychloroquine. Babies whose mothers are not on hydroxychloroquine can also have these reactions. When any drug trial takes place all reactions/symptoms that occur during the trial have to be recorded. Some of these are not necessarily a side effect of the drug but it has to be written up as a possible one simply because it occurred during the trial. Of these, 118 women used the DMARD during their pregnancy or while breastfeeding, with 149 children exposed to hydroxychloroquine during the neonatal or postnatal periods. The majority of women n = 76 used the drug during pregnancy and breastfeeding, 42 during pregnancy only, and 4 only while they were breastfeeding. Hydroxychloroquine Breastfeeding Warnings Some experts do not recommend breastfeeding during therapy with this drug. Infants exposed to this drug during breastfeeding receive only small amounts of the drug. In a small number of infants up to at least 1 year of age, careful follow-up found no adverse effects on growth, vision, or hearing.