Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Plaquenil stopped working Increase in malaria deaths after chloroquine failure Hydroxychloroquine tremor Uncontrolled eye movements unsteadiness, trembling, or other problems with muscle control or coordination vomiting Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects. For the Consumer. Continuing ringing or buzzing or other unexplained noise in the ears. feeling of constant movement of self or surroundings. irritability. nausea. nervousness. nightmares. sensation of spinning. shakiness and unsteady walk. uncontrolled eye movements. unsteadiness, trembling, or. Take this medication with a meal or a glass of milk to prevent stomach upset. Common side effects include nausea, loss of appetite, headache, and diarrhea. Plaquenil can cause blurred vision and dizziness. Do not drive or operate heavy machinery until you know how it affects you. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Side effects of plaquenil on the eyes Plaquenil, Plaquenil Side Effects Common, Severe, Long Term - Hydroxychloroquine for tall thin patient Common Side Effects of Plaquenil. Tell your doctor if any of the following side effects, as they may be indications of a more serious reaction Headache; Loss of appetite; Dizziness; Nausea Plaquenil Hydroxychloroquine - Side Effects, Dosage.. Plaquenil - Side Effects, Uses, Dosage, Overdose, Pregnancy.. What can Hydroxychloroquine Plaquenil do to my eyes?. This means that the side effects of Plaquenil are mild and infrequent compared with its potential benefits. As with any medication, allergic reactions including skin rashes and non-allergic reactions can occur. The side effect that is of greatest concern is retinal toxicity. Plaquenil. Uses. Hydroxychloroquine is used to prevent or treat malaria infections caused by mosquito bites. It does not work against certain types of. Side Effects. Precautions. Interactions. One of the most serious side effects is a toxicity in the eye generally with chronic use. People taking 400 mg of hydroxychloroquine or less per day generally have a negligible risk of macular toxicity, whereas the risk begins to go up when a person takes the medication over 5 years or has a cumulative dose of more than 1000 grams. The daily safe maximum dose for eye toxicity can be computed.