Why both chloroquine and primaquine

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  1. menod User

    Why both chloroquine and primaquine


    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

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    Primaquine is active as a chloroquine-resistance reverser at concentrations that could be clinically relevant. As primaquine and chloroquine are already used together in the treatment of P. vivax, this is potentially a cheap way of reviving and extending the life of chloroquine. Primaquine's production and use as an antimalarial may result in its release to the environment through various waste streams. If released to air, an estimated vapor pressure of 9.9X10-6 mm Hg at 25 °C indicates primaquine will exist in both the vapor and particulate phases in the atmosphere. Methods and findings. Patients with normal glucose-6-phosphate dehydrogenase status with symptomatic P.vivax mono-infection were enrolled and randomly assigned to receive either chloroquine CQ or artemether-lumefantrine AL, alone or in combination with 14 d of semi-supervised primaquine PQ 3.5 mg/kg total.

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    Why both chloroquine and primaquine

    Chloroquine Aralen - Side Effects, Dosage, Interactions - Drugs, Primaquine C15H21N3O - PubChem

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  6. Primaquine comes as a tablet to take by mouth. It is usually taken once a day for 14 days. Take primaquine at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand.

    • Primaquine MedlinePlus Drug Information.
    • Comparison of artemether-lumefantrine and chloroquine with and without..
    • Primaquine - FDA prescribing information, side effects and uses.

    In Mexico, combined chloroquine CQ and primaquine PQ treatment has been used since the late 1950s to treat Plasmodium vivax infections. Although malaria transmission has declined, current treatment strategies must be evaluated to advance towards malaria elimination. The clinical and parasitological outcome of treating symptomatic P. vivax with the 14-day T14 treatment or intermittent. Both the treatment arms offer evidence of good tolerability and efficacy. In other previous study performed in an area with high chloroquine-resistance Southern Papua, Indonesia, DHA-PQP was compared to ASAQ, but never compared to chloroquine by itself in areas where chloroquine still works. Primaquine should not be administered to anyone with G6PD deficiency because a severe reaction can occur, resulting in hemolytic anemia. However, the WHO has recommended that a single dose of primaquine 0.25 mg/kg is safe to give even in individuals with G6PD deficiency, for the purpose of preventing transmission of P. falciparum malaria.

     
  7. phd XenForo Moderator

    Chloroquine is the generic form of the brand-name prescription medicine Aralen, which is used to prevent and treat malaria — a mosquito-borne disease caused by a parasite — and to treat amebiasis, an infection of the intestines caused by a parasite. Hydroxychloroquine Plaquenil - Hydroxychloroquine Plaquenil thread COVID19 Chloroquine Indications, Side Effects, Warnings -
     
  8. Dark Lord User

    Plaquenil, Plaquenil Sulfate, Quineprox hydroxychloroquine Uses, Side. Drug Information on Plaquenil, Plaquenil Sulfate, Quineprox hydroxychloroquine includes side effects, uses, drug interactions, dosage, drug pictures, overdose symptoms, and what to avoid.

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