There are hundreds of drugs with potential retinal toxicity—so many that the National Registry of Drug-Induced Ocular Side Effects doesn’t stratify them by incidence or effect, said Frederick W. “Rick” Fraunfelder, MD, director of the Registry and associate professor of ophthalmology at Oregon Health & Science University in Portland. Mechanism of action hydroxychloroquine Plaquenil myasthenia gravis A metabolite of chloroquine – hydroxychloroquine – has a long half-life 32–56 days in blood and a large volume of distribution 580–815 L/kg. The therapeutic, toxic and lethal ranges are usually considered to be 0.03 to 15 mg/l, 3.0 to 26 mg/l and 20 to 104 mg/l, respectively. Nov 09, 2018 Hydroxychloroquine is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. This medicine is not effective against all strains of malaria. There is very limited data on pediatric hydroxychloroquine overdoses and no reports of toxicity from 1–2 pills, but given its similarity to chloroquine, it also should be considered potentially toxic at small doses. Thus, similar recommendations should be followed for triage after accidental hydroxychloroquine overdose. “It’s a pretty rare thing.” Nevertheless, he urged doctors to master the Academy’s new guidelines, because the effects from chloroquine and hydroxychloroquine, when they do occur, are severe and often irreversible. “Plaquenil toxicity isn’t even in the top 10, or the top 100” if you’re looking at incidence, he said. How dangerous is hydroxychloroquine Plaquenil Uses, Dosage & Side Effects -, Hydroxychloroquine - Side Effects, Dosage, Interactions. What is in plaquenilPlaquenil toxicity autofluorescence Although hydroxychloroquine is widely used in Spain, mainly in application to rheumatological disorders, very few cases of intoxication caused by this drug have been reported to date. The present clinical case describes the basic characteristics of hydroxychloroquine intoxication, and provides a review of the guidelines for using the drug. Hydroxychloroquine, a potentially lethal drug Medicina.. Are 1–2 dangerous? Chloroquine and hydroxychloroquine.. Hydroxychloroquine Plaquenil. Plaquenil Hydroxychloroquine is used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as lupus & others. Hydroxychloroquine is a quinoline medicine used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. This medicine is not effective against all strains of malaria. Plaquenil hydroxychloroquine Plaquenil hydroxychloroquine has many side effects. Some common ones include dizziness, abdominal pain, headache, nausea, diarrhea, itching, and sensitiviy to sun. More serious side effects which are more rare include certain types of anemia.