Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. What are the side effects of hydroxychloroquine sulfate Round hydroxychloroquine Find information about common, infrequent and rare side effects of Plaquenil Oral. Protecting your eyesight when taking Plaquenil. With all of the physical and emotional complications that lupus can cause, it’s easy to overlook symptoms that seem minor at first. But take this advice Don’t ignore changes in vision. Plaquenil should be administered with caution in patients having glucose-6-phosphate dehydrogenase G-6-PD deficiency. Dermatologic Effects Dermatologic reactions to Plaquenil may occur and, therefore, proper care should be exercised when it is administered to any patient receiving a drug with a significant tendency to produce dermatitis. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Plaquenil side effects loss of balance Plaquenil Side Effects Common, Severe, Long, Protecting your eyesight when taking Plaquenil Lupus. Chloroquine and fluoroquinolone dissertationChloroquine phosphate in myocardial protectionHydroxychloroquine interaction with gabapentinChloroquine mechanism of action in rheumatoid arthritis Loss of hearing. lower back or side pain. noisy breathing. painful or difficult urination. red irritated eyes. red skin lesions, often with a purple center. severe mood or mental changes. sore throat sores, ulcers, or white spots on the lips or in the mouth. sticking out of the tongue. stomach pain. swelling of the feet or lower legs. swollen or painful glands Plaquenil Side Effects - GoodRx. Plaquenil - FDA prescribing information, side. Rx Side Effects New Plaquenil Guidelines and More - American.. This medication is associated with following side effects loss of balance or coordination. muscle weakness, twitching, or uncontrolled movement. pale skin, easy bruising or bleeding. blurred vision, light sensitivity, seeing halos around light. seizure convulsions confusion, unusual thoughts or behavior. Incidentally, I asked him why plaquenil causes hair loss, and he said no one knows why. It's just one of those drugs known to have that side effect. Nothing to really help it he said, other than taking folic acid, b12 and biotin. I asked him about methotrexate, and he said he was on it for years for his RA and never had any major side effects. The Plaquenil drug side effects list weight loss, but some people have reported weight gain instead. What's happened with you? My rheumy wants me to come down and then off my Plaquenil, but I've been resisting simply because I'm afraid to.