Pattern of Retinopathy: Although the locus of toxic damage is parafoveal in many eyes, Asian patients often show an extramacular pattern of damage. Dose: We recommend a maximum daily HCQ use of 5.0 mg/kg real weight, which correlates better with risk than ideal weight. Plaquenil osteoarthritis treatment Lupus hydroxychloroquine sulfate The finding of corneal verticillata bares no correlation with retinal toxicity and is not an indication to stop the medication. The hallmark of hydroxychloroquine toxicity is bilateral pigmentary retinopathy 1. SIDE EFFECTS. The following adverse reactions have been identified during post-approval use of PLAQUENIL or other 4-aminoqunoline compounds. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. Corneal verticillata, also called vortex keratopathy, are one type of corneal deposits. Verticillata are readily recognizable by their distinct appearance as fine, golden-brown or gray opacities that are almost always bilateral. The opacities branch out from a central whorl, usually across the inferior cornea. The most common causes of verticillata include Amiodarone Risk of Toxicity: The risk of toxicity is dependent on daily dose and duration of use. There are no similar demographic data for CQ, but dose comparisons in older literature suggest using 2.3 mg/kg real weight. Plaquenil corneal verticillata Cornea verticillata, causes, symptoms, diagnosis & treatment, Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses Plaquenil sun allergyWhat is the half life of plaquenil Corneal verticillata is recognizable as fine golden-brown or gray opacities in the basal epithelium that branch out from a central whorl, usually across the inferior cornea. The deposits do not stain and are almost always bilateral. Cornea Verticillata - EyeWiki. Corneal verticillata - Amiodarone. Chloroquine Toxicity, Cornea Verticillata SpringerLink. Sep 15, 2014 The corneal deposits, known as verticillata, are asymptomatic, reversible, and not considered an indication to stop the medication. Unlike the benign verticillata, retinal toxicity can be visually significant, is largely irreversible, and can progress after cessation of the medication. Corneal deposits called vortex keratopathy or corneal verticillata result from binding to cellular lipids and deposition of the drug in the basal epithelial layer of the cornea. Discontinuation of the drug usually causes the deposits to disappear over time. Corneal verticillata, or vortex keratopathy, manifests as a whorl-like pattern of golden brown or gray deposits in the inferior interpalpebal portion of the cornea in a clockwise fashion Fig 12-15. A variety of medications bind with the cellular lipids of the basal epithelial layer of the cornea due to their cationic, amphiphilic properties.