Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it. Plaquenil exfoliative dermatitis Plaquenil and borderline personality disorder Chloroquine resistant malaria definition Chloroquine also known as chloroquine phosphate is an antimalarial medicine. It is available in the United States by prescription only. Purpose Chloroquine is a strong lysosomotropic and DNA-intercalating agent in experimental studies Neurosurgical Focus 142 February, 2003 and an open-label clinical trial the investigators have demonstrated a strong adjuvant effect of chloroquine on the therapy of malignant gliomas. J. Am. Chem. Soc. All Publications/Website. OR SEARCH CITATIONS The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead. Chloroquine intercalating Chloroquine Phosphate - TOKU-E, Chloroquine for Treatment of Glioblastoma Multiforme RxWiki What is hydroxychloroquine side effectsCan you get plaquenil in a injectionPlaquenil-tablets uses Antimalarial drug chloroquine. This activity was mitigated by the addition of plasmid DNA, suggest-ing that these compounds act against parasites by intercalating into their DNA. Key words antimalarial agents; quinomycin A; DNA intercalation Malaria is one of the most serious infectious diseases in many tropical and subtropical countries. Due. Inhibition of malaria parasite growth by quinomycin A and.. Synthetic models related to DNA intercalating molecules.. Chloroquine as intercalator a hypothesis revived - ScienceDirect. Uses Chloroquine is used to prevent or treat malaria caused by mosquito bites in countries where malaria is common. Malaria parasites can enter the body through these mosquito bites, and then live. Chloroquine is a well known anti-malarial agent, apart from which is a lysosomotropic agent, was used along with intercalating agent like methylene blue and anti-viral agents to treat clinically confirmed CHB patients. Mechanism of Action Chloroquine, a 4-aminoquinoline, is an anti-protozoal agent. The precise mechanism by which Chloroquine exhibits activity is not known. Chloroquine, may exert its effect against Plasmodium species by concentrating in the acid vesicles of the parasite and by inhibiting polymerization of heme.