Pharmacokinetics of chloroquine in rats

Discussion in 'Plaquenil' started by Eraserhead, 28-Feb-2020.

  1. Force111 Moderator

    Pharmacokinetics of chloroquine in rats

    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

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    The single oral dose pharmacokinetics of chloroquine was studied alone and after coadministration with phytomedicines NIPRID/92/001/1-1 AM-1, Niprisan®, and Nifadin® in rats. Plasma chloroquine concentrations were measured using High performance liquid chromatography HPLC method developed earlier in our laboratory. The data were fitted into a WinNonlin standard non-compartmental. Data for allometric scaling were obtained from 6 animal studies mice, rats, rabbits, monkeys. Pharmacokinetics of chloroquine in Thais plasma and red-cell concentrations following an intravenous infusion to healthy subjects and patients with Plasmodium vivax malaria. Ono C, Yamada M, Tanaka M. Absorption, distribution and excretion of 14C-chloroquine after single oral administration in albino and pigmented rats binding characteristics of chloroquine-related radioactivity to melanin in-vivo. J Pharm Pharmacol. 2003;47–54. PubMed Google Scholar

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    Pharmacokinetics of chloroquine in rats

    Pharmacokinetics of the Antimalarial Drug, AQ-13, in Rats., Pharmacokinetics, Pharmacodynamics, and Allometric Scaling.

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  7. Chloroquine is a medication used to prevent and to treat malaria in areas where malaria is known to be sensitive to its effects. Certain types of malaria, resistant strains, and complicated cases typically require different or additional medication.

    • Chloroquine - Wikipedia.
    • Pharmacology of Chloroquine and Hydroxychloroquine SpringerLink.
    • Pharmacokinetics of the Antimalarial Drug, AQ-13, in Rats and..

    Evaluation of the effect of some common Nigerian vegetables on the Pharmacokinetics of Chloroquine and Dihydroartemisinin in rat. 6 Vol 3, Isuue 2, 2013. The pharmacokinetics of chloroquine do not differ to a clinically important extent between black and white patients 11, 69, 79. The average melanin content of a black person is estimated to be 1 g and for a white person is estimated to be 250 mg. Experientia 38, 1326-1327. Adelusi S. A. and Salako L. A. 19a Kinetics of the distribution and elimination of chloroquine in the rat. Gen. Pharmac. 13, 433-437. Adelusi S. A. and Salako L. A. 19b The effect of protein-energy malnutrition on the absorption, distribution and elimination of chloroquine in the rat. Gen. Pharmac. 13, 505-509.

  8. libovi Guest

    Applies to hydroxychloroquine: oral tablet Along with its needed effects, hydroxychloroquine (the active ingredient contained in Plaquenil) may cause some unwanted effects. Plaquenil Uses, Dosage & Side Effects - The Risk of Retinal Toxicity with Plaquenil Plaquenil side effects - kidney problems? - Symptoms.
  9. Miren Guest

    Joint damage worries and aching hands are no fun, and if you’re experiencing those kinds of problems because of rheumatoid arthritis you may have options that can help you feel better. Hydroxychloroquine Plaquenil and Breast Feeding — The Bump HYDROXYCHLOROQUINE SULFATE Plaquenil® Adults Prescribing. Hydroxychloroquine Plaquenil
  10. alcher New Member

    CHLOROQUINE DIPHOSPHATE IN RHEUMATOID ARTHRITIS* Polyarthritic syndromes other thanrheumatoid arthritis, in separate controlled groups, but the numbers of patients in these other categories were too small for analysis. This report therefore deals only with the results of treatment with chloroquine in patients with an inflammatory polyarthritis of rheumatoid type.

    Diagnosis and Management of Rheumatoid Arthritis - American.
  11. kamiury Moderator

    Chloroquine – howMed Mechanism of action of chloroquine. Entry into the parasitized RBCs; 1. Accumulation in food vacuole of the parasite- role of pH gradient chloroquine trapping Affects asexual cycle of plasmodium specie. Once administered, it has to enter site of action. It rapidly enters and gets concentrated in food vacuole, present within erythrocytes.

    Hydroxychloroquine DermNet NZ